BindingDB BDBM21190 4-(2-{[5-amino-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-7-yl]amino}ethyl)phenol::CHEMBL113142::ZM 241385::ZM241385::[3H]-ZM241385

BDBM21190 4-(2-{[5-amino-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-7-yl]amino}ethyl)phenol::CHEMBL113142::ZM 241385::ZM241385::[3H]-ZM241385

SMILES Nc1nc(NCCc2ccc(O)cc2)nc2nc(nn12)-c1ccco1

InChI Key InChIKey=PWTBZOIUWZOPFT-UHFFFAOYSA-N

Data 108 KI 16 IC50 4 Kd 2 EC50

PDB links: 30 PDB IDs match this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 21190

Adenosine receptor A2b(Homo sapiens (Human))
University of Bonn

Curated by ChEMBL

BDBM21190(4-(2-{[5-amino-2-(furan-2-yl)-[1,2,4]triazolo[1,5-...)

IC50: 95nMAssay Description:Displacement of PSB-12105 from recombinant human adenosine A2B receptor expressed in CHO cell membranes preincubated for 30 mins followed by PSB-1210...More data for this Ligand-Target Pair

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Filter my 130 hits

Targets 7▿
- Adenosine receptor A2a 65
- Adenosine receptor A1 28
- Adenosine receptor A2b 20
- Adenosine receptor A3 13
- D(2) dopamine receptor 2
- Histone deacetylase 6 1
- Histone deacetylase 1 1
- ...
Publications 45▿
- J Med Chem 62: 9315-9330 (2019) 8
- Eur J Med Chem 187: (2020) 8
- J Med Chem 59: 10564-10576 (2016) 7
- Eur J Med Chem 155: 552-561 (2018) 6
- Mol Pharmacol 56: 705-13 (1999) 5
- Bioorg Med Chem Lett 30: (2020) 5
- J Med Chem 64: 458-480 (2021) 4
- Naunyn Schmiedebergs Arch Pharmacol 359: 7-10 (1999) 4
- J Med Chem 60: 3372-3382 (2017) 4
- J Med Chem 57: 3623-50 (2014) 4
- J Med Chem 63: 7721-7739 (2020) 4
- Mol Pharmacol 61: 415-24 (2002) 4
- Bioorg Med Chem Lett 23: 3427-33 (2013) 4
- J Med Chem 65: 2091-2106 (2022) 4
- J Med Chem 58: 718-38 (2015) 4
- J Med Chem 59: 1967-83 (2016) 4
- J Med Chem 52: 7640-52 (2009) 3
- J Med Chem 47: 4291-9 (2004) 3
- ACS Med Chem Lett 13: 1172-1181 (2022) 3
- Eur J Med Chem 144: 151-163 (2018) 3
- J Med Chem 63: 12196-12212 (2020) 3
- J Med Chem 64: 16573-16597 (2021) 3
- Br J Pharmacol 115: 1096-102 (1995) 2
- Bioorg Med Chem 23: 6641-9 (2015) 2
- J Med Chem 59: 6470-9 (2016) 2
- J Med Chem 48: 2009-18 (2005) 2
- Eur J Med Chem 44: 2122-7 (2009) 2
- J Med Chem 48: 6887-96 (2005) 2
- Bioorg Med Chem Lett 26: 734-8 (2016) 2
- Eur J Med Chem 227: (2022) 2
- J Med Chem 51: 1730-9 (2008) 2
- Bioorg Med Chem Lett 14: 3307-12 (2004) 2
- J Med Chem 51: 4449-55 (2008) 1
- Bioorg Med Chem Lett 15: 4809-13 (2005) 1
- Bioorg Med Chem 18: 2081-8 (2010) 1
- Eur J Med Chem 241: (2022) 1
- J Med Chem 62: 8511-8531 (2019) 1
- Eur J Med Chem 108: 529-41 (2016) 1
- J Med Chem 54: 4312-23 (2011) 1
- ACS Med Chem Lett 8: 660-665 (2017) 1
- J Med Chem 61: 4301-4316 (2018) 1
- J Med Chem 59: 788-809 (2016) 1
- J Med Chem 51: 1719-29 (2008) 1
- Eur J Med Chem 104: 177-88 (2015) 1
- J Med Chem 39: 398-406 (1996) 1
Institutions 28▿
- Uppsala University 20
- Universit£ 20
- North-West University 10
- Nankai University 8
- Monash University (Parkville Campus) 8
- Universidade De Santiago De Compostela 8
- Biogen Idec 6
- University of Virginia 5
- Merck Research Laboratories 4
- University of Ferrara 4
- Schering-Plough Research Institute 4
- Neuroscience 3
- Shanghaitech University 3
- Fudan University 3
- Umr-S1172 - Jparc - Centre De Recherche Jean-Pierre Aubert Neurosciences Et Cancer 3
- University Of Dundee 3
- Heptares Therapeutics 3
- Zeneca Pharmaceuticals 2
- Isf College Of Pharmacy 2
- University Institute Of Pharmaceutical Sciences 2
- F. Hoffmann-La Roche 2
- Kissei Pharmaceutical 1
- National Institute of Diabetes 1
- Univ. Lille 1
- University of Bonn 1
- Universidad De M£Laga 1
- Leiden/Amsterdam Center For Drug Research 1
- Georgia Institute Of Technology 1
Affinity: 0.10 to 9.9E+8 nM▿
- Ki 108
- IC50 16
- Kd 4
- EC50 2
- Affinity ≤ nM
Xtal structures: 1
Docked structures: 0
Catalog Cmpds: 1