BDBM50247053 1-(3-(3-(4-chlorophenyl)propoxy)propyl)piperidine::CHEMBL462605::Tiprolisant
SMILES Clc1ccc(CCCOCCCN2CCCCC2)cc1
InChI Key InChIKey=NNACHAUCXXVJSP-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 24 hits for monomerid = 50247053
Affinity DataKi: 0.160nMAssay Description:Antagonist activity at human histamine H3 receptor expressed in HEK293 cells by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
Affinity DataKi: 0.300nMAssay Description:Inhibition of human H3 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 0.300nMAssay Description:Binding affinity to human H3RMore data for this Ligand-Target Pair
Affinity DataKi: 0.300nMAssay Description:Binding affinity to human histamine H3 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 2.40nMAssay Description:Displacement of [125I]Iodoproxyfran from human histamine H3 receptor expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 2.70nMAssay Description:Displacement of [125I]Iodoproxyfran from human histamine H3 receptor expressed in rat C6 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 2.70nMAssay Description:Displacement of [125I]-iodoproxyfan from human striatal full length H3 receptor after 60 mins by gamma counting methodMore data for this Ligand-Target Pair
Affinity DataKi: 12nMAssay Description:Displacement of [3H]-N-alpha-methylhistamine from human histamine H3 receptor stably expressed in HEK293 cell membrane after 90 minsMore data for this Ligand-Target Pair
Affinity DataKi: 12nMAssay Description:Displacement of [3H]N-alpha-Methylhistamine from recombinant human histamine H3 receptor expressed in human HEK293 cells incubated for 90 mins by mic...More data for this Ligand-Target Pair
Affinity DataKi: 12nMAssay Description:Displacement of [3H]-N-alpha-methylhistamine from human recombinant full length H3R expressed in HEK293 cell membranes incubated for 90 mins by liqui...More data for this Ligand-Target Pair
Affinity DataKi: 14nMAssay Description:Displacement of [125I]-iodoproxyfan from mouse brain cortex H3 receptor after 60 mins by gamma counting methodMore data for this Ligand-Target Pair
Affinity DataKi: 14.8nMAssay Description:Displacement of [125I]Iodoproxyfran from human histamine H3 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 17nMAssay Description:Binding affinity to rat histamine H3 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 17nMAssay Description:Binding affinity to histamine H3 receptor in rat cerebral cortexMore data for this Ligand-Target Pair
Affinity DataKi: 17nMAssay Description:Displacement of [125I]-iodoproxyfan from rat brain cortex H3 receptor after 60 mins by gamma counting methodMore data for this Ligand-Target Pair
Affinity DataKi: 17nMAssay Description:Binding affinity to rat H3RMore data for this Ligand-Target Pair
Affinity DataKi: 30nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from recombinant human histamine H3 receptor expressed in CHO-K1 cells by microbeta scintillation analysi...More data for this Ligand-Target Pair
Affinity DataKi: >1.00E+5nMAssay Description:Inhibition of human H4 receptorMore data for this Ligand-Target Pair
Affinity DataKi: >1.00E+5nMAssay Description:Binding affinity to human H4RMore data for this Ligand-Target Pair
Affinity DataKd: 5.62nMAssay Description:Antagonist activity at histamine H3 receptor in isolated guinea pig ileumMore data for this Ligand-Target Pair
Affinity DataIC50: 8.42E+3nMAssay Description:Inhibition of equine serum BChE using butyrylthiocholine iodide as substrate preincubated with enzyme for 5 mins prior to substrate addition measured...More data for this Ligand-Target Pair
Affinity DataIC50: 8.40E+3nMAssay Description:Inhibition of equine serum BChE using BTCI as substrate incubated for 5 mins followed by substrate addition and measured after 5 mins by spectrophoto...More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Jagiellonian University Medical College
Curated by ChEMBL
Jagiellonian University Medical College
Curated by ChEMBL
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of human ERG expressed in CHO cells at holding potential of -90 mV by patch clamp methodMore data for this Ligand-Target Pair
Affinity DataEC50: 1.5nMAssay Description:Antagonist activity at human histamine H3 receptor expressed in CHO-K1 cells by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair