BindingDB BDBM50447094 CHEMBL1972466

BDBM50447094 CHEMBL1972466

SMILES CC(Nc1ccccc1)c1cc(C)cn2c1nc(cc2=O)N1CCOCC1

InChI Key InChIKey=CPRAGQJXBLMUEL-UHFFFAOYSA-N

Data 19 IC50

PDB links: 1 PDB ID matches this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50447094

Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL

BDBM50447094(CHEMBL1972466)

IC50: 63nMAssay Description:Inhibition of recombinant human full-length N-terminal His6-tagged p110beta/human recombinant full-length untagged p85alpha expressed in baculovirus ...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar

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Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL

BDBM50447094(CHEMBL1972466)

IC50: 7.60E+3nMAssay Description:Inhibition of human full length p110alpha/p85alpha using PIP2 as substrate after 30 mins in presence of ATP at 2xKm concentration by TR-FRET assayMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar

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Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL

BDBM50447094(CHEMBL1972466)

IC50: 500nMAssay Description:Inhibition of human p110delta catalytic subunit/p85alpha using PIP2 as substrate after 30 mins in presence of ATP at 2xKm concentration by TR-FRET as...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar

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Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL

BDBM50447094(CHEMBL1972466)

IC50: >1.00E+4nMAssay Description:Inhibition of human full length p110gamma using PIP2 as substrate after 30 mins in presence of ATP at 2xKm concentration by TR-FRET assayMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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Details Article PubMed

Filter my 19 hits

Targets 7▿
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform 8
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform 4
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform 2
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform 2
- Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform 1
- Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit beta isoform 1
- Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform 1
Publications 8▿
- J Med Chem 57: 903-20 (2014) 5
- ACS Med Chem Lett 11: 1236-1243 (2020) 4
- Bioorg Med Chem 23: 3796-808 (2015) 3
- J Med Chem 58: 41-71 (2015) 2
- Bioorg Med Chem Lett 24: 3936-43 (2014) 2
- Bioorg Med Chem 69: (2022) 1
- Eur J Med Chem 122: 339-351 (2016) 1
- Bioorg Med Chem Lett 24: 3928-35 (2014) 1
Institutions 7▿
- Sanofi 5
- Gilead Sciences 4
- Astrazeneca 3
- University Of Auckland 3
- University Hospital Hradec Kralove 2
- Monash University 1
- La Trobe University 1
Affinity: 4 to 1.0E+4 nM▿
- IC50 19
- Affinity ≤ nM
Xtal structures: 0
Docked structures: 0
Catalog Cmpds: 1