BDBM5445 CHEMBL554::GW572016::LAPATINIB DITOSYLATE::Lapatinib::N-{3-chloro-4-[(3-fluoro-benzyl)oxy]phenyl}-6-[5-({2-(methylsulfonyl)ethyl]amino}methyl)-2-furyl]-4-quinazolinamine::N-{3-chloro-4-[(3-fluorophenyl)methoxy]phenyl}-6-(5-{[(2-methanesulfonylethyl)amino]methyl}furan-2-yl)quinazolin-4-amine::Tykerb::US10507209, Compound Lapatinib::US10822334, Compound Lapatinib::US9730934, Lapatinib ditosylate::cid_208908
SMILES CS(=O)(=O)CCNCc1ccc(o1)-c1ccc2ncnc(Nc3ccc(OCc4cccc(F)c4)c(Cl)c3)c2c1
InChI Key InChIKey=BCFGMOOMADDAQU-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 3 hits for monomerid = 5445
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Jiangsu Aosaikang Pharmaceutical
Curated by ChEMBL
Jiangsu Aosaikang Pharmaceutical
Curated by ChEMBL
Affinity DataIC50: 62nMAssay Description:Inhibition of EGFR in human KB cells assessed as reduction in EGF-stimulated EGFR phosphorylation preincubated for 1 hr followed by EGF stimulation a...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Jiangsu Aosaikang Pharmaceutical
Curated by ChEMBL
Jiangsu Aosaikang Pharmaceutical
Curated by ChEMBL
Affinity DataIC50: 22nMAssay Description:Inhibition of EGFR (unknown origin) using FAM-labeled peptide as substrate preincubated for 10 mins followed by substrate addition measured after 40 ...More data for this Ligand-Target Pair
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Jiangsu Aosaikang Pharmaceutical
Curated by ChEMBL
Jiangsu Aosaikang Pharmaceutical
Curated by ChEMBL
Affinity DataIC50: 13nMAssay Description:Inhibition of HER2 (unknown origin) using FAM-labeled peptide as substrate preincubated for 10 mins followed by substrate addition measured after 40 ...More data for this Ligand-Target Pair