BDBM50292406 CHEMBL485053::leucettamine B

SMILES CN1C(N)=NC(=Cc2ccc3OCOc3c2)C1=O

InChI Key InChIKey=PKEDBIGNILOTHW-UHFFFAOYSA-N

Data  1 KI  50 IC50  3 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 19 hits for monomerid = 50292406   

TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Cnrs

Curated by ChEMBL
LigandPNGBDBM50292406(CHEMBL485053 | leucettamine B)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human recombinant PIM1 expressed in Escherichia coli using histone H1 as substrate and [gamma33P]ATP after 30 mins by scintillation cou...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Cnrs

Curated by ChEMBL
LigandPNGBDBM50292406(CHEMBL485053 | leucettamine B)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human recombinant GSK3beta expressed in insect cells using YRRAAVPPSPSLSRHSSPHQ-phosphoS-EDEEE as substrate and [gamma33P]ATP after 30 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 alpha(Homo sapiens (Human))
Cnrs

Curated by ChEMBL
LigandPNGBDBM50292406(CHEMBL485053 | leucettamine B)
Affinity DataIC50:  7.70E+3nMAssay Description:Inhibition of human recombinant GSK3alpha expressed in insect cells using YRRAAVPPSPSLSRHSSPHQ-phosphoS-EDEEE as substrate and [gamma33P]ATP after 30...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 1(Rattus norvegicus (rat))
Cnrs

Curated by ChEMBL
LigandPNGBDBM50292406(CHEMBL485053 | leucettamine B)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of rat recombinant ERK2 using Ets1 as substrate and [gamma33P]ATP as substrate after 30 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50292406(CHEMBL485053 | leucettamine B)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human recombinant GST-tagged DYRK4 expressed in Escherichia coli using GRSRSRSRSRSR as substrate and [gamma33P]ATP after 30 mins by sci...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50292406(CHEMBL485053 | leucettamine B)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibition of human recombinant GST-tagged DYRK3 expressed in Escherichia coli using GRSRSRSRSRSR as substrate and [gamma33P]ATP after 30 mins by sci...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50292406(CHEMBL485053 | leucettamine B)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of human recombinant GST-tagged DYRK2 expressed in Escherichia coli using GRSRSRSRSRSR as substrate and [gamma33P]ATP after 30 mins by sci...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50292406(CHEMBL485053 | leucettamine B)
Affinity DataIC50:  4.10E+3nMAssay Description:Inhibition of human recombinant GST-tagged DYRK1B expressed in Escherichia coli using GRSRSRSRSRSR as substrate and [gamma33P]ATP after 30 mins by sc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50292406(CHEMBL485053 | leucettamine B)
Affinity DataIC50:  950nMAssay Description:Inhibition of human recombinant C-terminal truncated GST-tagged DYRK1A expressed in Escherichia coli using GRSRSRSRSRSR as substrate and [gamma33P]AT...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50292406(CHEMBL485053 | leucettamine B)
Affinity DataIC50:  600nMAssay Description:Inhibition of human recombinant full length GST-tagged DYRK1A expressed in Escherichia coli using GRSRSRSRSRSR as substrate and [gamma33P]ATP after 3...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50292406(CHEMBL485053 | leucettamine B)
Affinity DataIC50:  900nMAssay Description:Inhibition of rat DYRK1A isolated from brain using KKISGRLSPIMTEQ as substrate and [gamma33P]ATP after 30 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50292406(CHEMBL485053 | leucettamine B)
Affinity DataIC50:  920nMAssay Description:Inhibition of rat recombinant C-terminal truncated GST-tagged DYRK1A expressed in Escherichia coli using GRSRSRSRSRSR as substrate and [gamma33P]ATP ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein kinase CLK4(Mus musculus)
Cnrs

Curated by ChEMBL
LigandPNGBDBM50292406(CHEMBL485053 | leucettamine B)
Affinity DataIC50:  150nMAssay Description:Inhibition of mouse recombinant GST-tagged CLK4 expressed in Escherichia coli using GRSRSRSRSRSR as substrate and [gamma33P]ATP after 30 mins by scin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein kinase CLK3(Mus musculus)
Cnrs

Curated by ChEMBL
LigandPNGBDBM50292406(CHEMBL485053 | leucettamine B)
Affinity DataIC50:  1.80E+3nMAssay Description:Inhibition of mouse recombinant GST-tagged CLK3 expressed in Escherichia coli using GRSRSRSRSRSR as substrate and [gamma33P]ATP after 30 mins by scin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein kinase CLK2(Mus musculus)
Cnrs

Curated by ChEMBL
LigandPNGBDBM50292406(CHEMBL485053 | leucettamine B)
Affinity DataIC50:  2.10E+3nMAssay Description:Inhibition of mouse recombinant GST-tagged CLK2 expressed in Escherichia coli using GRSRSRSRSRSR as substrate and [gamma33P]ATP after 30 mins by scin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Homo sapiens (Human))
Cnrs

Curated by ChEMBL
LigandPNGBDBM50292406(CHEMBL485053 | leucettamine B)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human recombinant CDK9/cyclin T expressed in insect cell using YSPTSPSYSPTSPSYSPTSPSKKKK as substrate and [gamma33P]ATP after 30 mins b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-H/Cyclin-dependent kinase 7(Homo sapiens (Human))
Cnrs

Curated by ChEMBL
LigandPNGBDBM50292406(CHEMBL485053 | leucettamine B)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human recombinant CDK7/cyclin H expressed in insect cell using YSPTSPSYSPTSPSYSPTSPSKKKK as substrate and [gamma33P]ATP after 30 mins b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1(Homo sapiens (Human))
Cnrs

Curated by ChEMBL
LigandPNGBDBM50292406(CHEMBL485053 | leucettamine B)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human recombinant CDK5/p25 using histone H1 as substrate and [gamma33P]ATP after 30 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein kinase CLK1(Mus musculus)
Cnrs

Curated by ChEMBL
LigandPNGBDBM50292406(CHEMBL485053 | leucettamine B)
Affinity DataIC50:  66nMAssay Description:Inhibition of mouse recombinant GST-tagged CLK1 expressed in Escherichia coli using GRSRSRSRSRSR as substrate and [gamma33P]ATP after 30 mins by scin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed