BDBM50383274 CHEMBL1229592::US10167264, WZ4002::US9670213, WZ4002
SMILES COc1cc(ccc1Nc1ncc(Cl)c(Oc2cccc(NC(=O)C=C)c2)n1)N1CCN(C)CC1
InChI Key InChIKey=ITTRLTNMFYIYPA-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 3 hits for monomerid = 50383274
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Technische Universit£T Dortmund
Curated by ChEMBL
Technische Universit£T Dortmund
Curated by ChEMBL
Affinity DataIC50: 16nMAssay Description:Inhibition of wild type N-terminal His6-tagged human EGFR kinase domain (702 to 1016 residues) expressed in Sf9 cells pre-incubated for 30 mins befor...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Technische Universit£T Dortmund
Curated by ChEMBL
Technische Universit£T Dortmund
Curated by ChEMBL
Affinity DataIC50: 0.420nMAssay Description:Inhibition of GST-tagged human recombinant EGFR catalytic domain (668 to 1210 amino acids) L858R mutant expressed in Sf9 cells pre-incubated for 30 m...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Technische Universit£T Dortmund
Curated by ChEMBL
Technische Universit£T Dortmund
Curated by ChEMBL
Affinity DataIC50: 0.190nMAssay Description:Inhibition of GST-tagged human recombinant EGFR catalytic domain (668 to 1210 amino acids) T790M/L858R mutant expressed in Sf9 cells pre-incubated fo...More data for this Ligand-Target Pair