BDBM25116 1-tert-butyl-3-(4-methylphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine::CHEMBL306380::PP1::US10688093, Compound PP1 (Pfizer)::US10807986, Comparative compound 1::US11046696, Compound 1 of Comparative Examples::US11701353, PP1 (Pfizer)::cid_1400
SMILES Cc1ccc(cc1)-c1nn(c2ncnc(N)c12)C(C)(C)C
InChI Key InChIKey=ZVPDNRVYHLRXLX-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 8 hits for monomerid = 25116
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
University Of Edinburgh
Curated by ChEMBL
University Of Edinburgh
Curated by ChEMBL
Affinity DataIC50: 9.32E+3nMAssay Description:Inhibition of human mTOR using poly[Glu,Tyr]4:1 as substrate in presence of [gamma-33P]ATPMore data for this Ligand-Target Pair
TargetPlatelet-derived growth factor receptor alpha(Homo sapiens (Human))
University Of Edinburgh
Curated by ChEMBL
University Of Edinburgh
Curated by ChEMBL
Affinity DataIC50: 657nMAssay Description:Inhibition of human PDGFRalpha using poly[Glu,Tyr]4:1 as substrate in presence of [gamma-33P]ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 147nMAssay Description:Inhibition of human ABL using EAIYAAPFAKKK as substrate in presence of [gamma-33P]ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 27nMAssay Description:Inhibition of human FYN using poly[Glu,Tyr]4:1 as substrate in presence of [gamma-33P]ATPMore data for this Ligand-Target Pair
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
University Of Edinburgh
Curated by ChEMBL
University Of Edinburgh
Curated by ChEMBL
Affinity DataIC50: 1.32E+3nMAssay Description:Inhibition of human KIT using poly[Glu,Tyr]4:1 as substrate in presence of [gamma-33P]ATPMore data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
University Of Edinburgh
Curated by ChEMBL
University Of Edinburgh
Curated by ChEMBL
Affinity DataIC50: 11nMAssay Description:Inhibition of human RET using poly[Glu,Tyr]4:1 as substrate in presence of [gamma-33P]ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 36nMAssay Description:Inhibition of human YES using poly[Glu,Tyr]4:1 as substrate in presence of [gamma-33P] ATPMore data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
University Of Edinburgh
Curated by ChEMBL
University Of Edinburgh
Curated by ChEMBL
Affinity DataIC50: 17nMAssay Description:Inhibition of C-terminal His-tagged full length human SRC expressed in insect cells preincubated for 20 mins using poly[Glu,Tyr]4:1 as substrate meas...More data for this Ligand-Target Pair