BDBM50038649 2-(6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizin-5-yl)acetic acid::CHEMBL300982::Licofelone::ML-3000::[2-(4-Chloro-phenyl)-6,6-dimethyl-1-phenyl-6,7-dihydro-5H-pyrrolizin-3-yl]-acetic acid::[6-(4-CHLOROPHENYL)-2,2-DIMETHYL-7-PHENYL-2,3-DIHYDRO-1H-PYRROLIZIN-5-YL]ACETIC ACID
SMILES CC1(C)Cc2c(c(c(CC(O)=O)n2C1)-c1ccc(Cl)cc1)-c1ccccc1
InChI Key InChIKey=UAWXGRJVZSAUSZ-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 4 hits for monomerid = 50038649
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Bhupat And Jyoti Mehta School Of Biosciences
Curated by ChEMBL
Bhupat And Jyoti Mehta School Of Biosciences
Curated by ChEMBL
Affinity DataIC50: 500nMAssay Description:Inhibition of human recombinant 5-LOX expressed in Escherichia coli BL21 assessed as decrease in 5-HPETE production preincubated with enzyme followed...More data for this Ligand-Target Pair
TargetProstaglandin E synthase(Homo sapiens (Human))
Bhupat And Jyoti Mehta School Of Biosciences
Curated by ChEMBL
Bhupat And Jyoti Mehta School Of Biosciences
Curated by ChEMBL
Affinity DataEC50: 100nMAssay Description:Inhibition of mPGES1 in human A549 cells assessed as reduction in PGE2 productionMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Bhupat And Jyoti Mehta School Of Biosciences
Curated by ChEMBL
Bhupat And Jyoti Mehta School Of Biosciences
Curated by ChEMBL
Affinity DataIC50: 800nMAssay Description:Inhibition of COX-1 (unknown origin)More data for this Ligand-Target Pair
TargetProstaglandin E synthase(Homo sapiens (Human))
Bhupat And Jyoti Mehta School Of Biosciences
Curated by ChEMBL
Bhupat And Jyoti Mehta School Of Biosciences
Curated by ChEMBL
Affinity DataIC50: 6.00E+3nMAssay Description:Inhibition of mPGES1 in human HeLa cells assessed as reduction in TNF-alpha induced PGE2 production preincubated for 2 hrs followed by TNF-alpha addi...More data for this Ligand-Target Pair