BindingDB BDBM50004656 (2-Carbamoyloxy-ethyl)-trimethyl-ammonium::(2-Carbamoyloxyethyl)trimethylammonium chloride::(2-Hydroxyethyl)trimethyl ammonium chloride carbamate::(2-Hydroxyethyl)trimethylammonium chloride carbamate::(carbachol)(2-Carbamoyloxy-ethyl)-trimethyl-ammonium::2-((Aminocarbonyl)oxy)-N,N,N-trimethylethanaminium chloride::2-((Aminocarbonyl)oxy)-N,N,N-trimethylethanaminum chloride::2-(carbamoyloxy)-N,N,N-trimethylethanaminium::2-(carbamoyloxy)-N,N,N-trimethylethanaminium chloride::CARBACHOL::CARBASTAT::CHEMBL14::Carbachol chloride::Carbamylcholine::Choline carbamate chloride::Choline chloride, carbamate::Choline chlorine carbamate::Karbachol::Karbamoylcholin chlorid::MIOSTAT

BDBM50004656 (2-Carbamoyloxy-ethyl)-trimethyl-ammonium::(2-Carbamoyloxyethyl)trimethylammonium chloride::(2-Hydroxyethyl)trimethyl ammonium chloride carbamate::(2-Hydroxyethyl)trimethylammonium chloride carbamate::(carbachol)(2-Carbamoyloxy-ethyl)-trimethyl-ammonium::2-((Aminocarbonyl)oxy)-N,N,N-trimethylethanaminium chloride::2-((Aminocarbonyl)oxy)-N,N,N-trimethylethanaminum chloride::2-(carbamoyloxy)-N,N,N-trimethylethanaminium::2-(carbamoyloxy)-N,N,N-trimethylethanaminium chloride::CARBACHOL::CARBASTAT::CHEMBL14::Carbachol chloride::Carbamylcholine::Choline carbamate chloride::Choline chloride, carbamate::Choline chlorine carbamate::Karbachol::Karbamoylcholin chlorid::MIOSTAT

SMILES C[N+](C)(C)CCOC(N)=O

InChI Key InChIKey=VPJXQGSRWJZDOB-UHFFFAOYSA-O

Data 163 KI 40 IC50 3 Kd 73 EC50

PDB links: 4 PDB IDs match this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50004656

Muscarinic acetylcholine receptor M1/M2/M3/M4/M5(Homo sapiens (Human))
University Of California

Curated by ChEMBL

BDBM50004656((2-Carbamoyloxy-ethyl)-trimethyl-ammonium | (2-Car...)

Kd: 1.70E+4nMAssay Description:Dissociation constant of the drug-receptor complex was measured in guinea pig urinary bladderMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar

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CHEMBL DrugBank MCE
KEGG MMDB PC cid PC sid PDB Similars

Details Article PubMed DrugBank

Muscarinic acetylcholine receptor M1/M2/M3/M4/M5(Homo sapiens (Human))
University Of California

Curated by ChEMBL

BDBM50004656((2-Carbamoyloxy-ethyl)-trimethyl-ammonium | (2-Car...)

EC50: 620nMAssay Description:In vitro muscarinic activity was measured on isolated guinea pig urinary bladderMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar

Purchase ChEBI
CHEMBL DrugBank MCE
KEGG MMDB PC cid PC sid PDB Similars

Details Article PubMed DrugBank

Muscarinic acetylcholine receptor M1/M2/M3/M4/M5(Homo sapiens (Human))
University Of California

Curated by ChEMBL

BDBM50004656((2-Carbamoyloxy-ethyl)-trimethyl-ammonium | (2-Car...)

EC50: 110nMAssay Description:In vitro muscarinic activity was measured on isolated guinea pig ileumMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar

Purchase ChEBI
CHEMBL DrugBank MCE
KEGG MMDB PC cid PC sid PDB Similars

Details Article PubMed DrugBank

Filter my 279 hits

Targets 38▿
- Muscarinic acetylcholine receptor M3 65
- Muscarinic acetylcholine receptor M2 46
- Muscarinic acetylcholine receptor M1 46
- Muscarinic acetylcholine receptor M1/M2/M3/M4/M5 26
- Muscarinic acetylcholine receptor M4 24
- Muscarinic acetylcholine receptor M5 12
- Nicotinic acetylcholine receptor 10
- Neuronal acetylcholine receptor subunit alpha-4 5
- Muscarinic acetylcholine receptor M3 [1-273,470-589,N6Q,N15Q,N41Q,N48Q,N52Q] 3
- Neuronal acetylcholine receptor subunit alpha-3 3
- Neuronal acetylcholine receptor subunit alpha-7 2
- Muscarinic acetylcholine receptor M3 [1-273,470-589,N6Q,N15Q,N41Q,N48Q,N52Q,T556C] 2
- Beta-arrestin-1 2
- Neuronal acetylcholine receptor subunit alpha-4/beta-2 2
- Muscarinic acetylcholine receptor M3 [1-273,470-589,N6Q,N15Q,N41Q,N48Q,N52Q,T553C] 2
- Muscarinic acetylcholine receptor M3 [1-273,470-589,N6Q,N15Q,N41Q,N48Q,N52Q,R176C] 2
- Muscarinic acetylcholine receptor M3 [1-273,470-589,N6Q,N15Q,N41Q,N48Q,N52Q,F550C] 2
- Acetylcholinesterase 2
- Muscarinic acetylcholine receptor M3 [1-273,470-589,N6Q,N15Q,N41Q,N48Q,N52Q,T180C] 2
- Muscarinic acetylcholine receptor 2
- Neuronal acetylcholine receptor subunit alpha-2 2
- Neuronal acetylcholine receptor subunit alpha-3/beta-4 1
- Neuronal acetylcholine receptor subunit alpha-2/beta-2 1
- Muscarinic acetylcholine receptor M3 [1-273,470-589,N6Q,N15Q,N41Q,N48Q,N52Q,K178C] 1
- Neuronal acetylcholine receptor subunit alpha-3/beta-2 1
- Neuronal acetylcholine receptor subunit alpha-5 1
- Muscarinic acetylcholine receptor M3 [1-273,470-589,N6Q,N15Q,N41Q,N48Q,N52Q,A177C] 1
- Muscarinic acetylcholine receptor M3 [1-273,470-589,N6Q,N15Q,N41Q,N48Q,N52Q,F554C] 1
- Alpha-bungarotoxin 1
- Muscarinic acetylcholine receptor M3 [1-273,470-589,N6Q,N15Q,N41Q,N48Q,N52Q,T549C] 1
- Muscarinic acetylcholine receptor M3 [1-273,470-589,N6Q,N15Q,N41Q,N48Q,N52Q,K555C] 1
- Muscarinic acetylcholine receptor M3 [1-273,470-589,N6Q,N15Q,N41Q,N48Q,N52Q,K548C] 1
- Muscarinic acetylcholine receptor M3 [1-273,470-589,N6Q,N15Q,N41Q,N48Q,N52Q,R551C] 1
- Neuronal acetylcholine receptor subunit alpha-4/beta-4 1
- Muscarinic acetylcholine receptor M3 [1-273,470-589,N6Q,N15Q,N41Q,N48Q,N52Q,T552C] 1
- Promotilin 1
- Muscarinic acetylcholine receptor M3 [1-273,470-589,N6Q,N15Q,N41Q,N48Q,N52Q,R179C] 1
- Bile salt export pump 1
- ...
Publications 50▿
- J Biol Chem 282: 26284-93 (2007) 42
- J Biol Chem 288: 34777-90 (2013) 22
- J Med Chem 41: 2047-55 (1998) 14
- J Pharmacol Exp Ther 310: 98-107 (2004) 7
- J Med Chem 57: 9065-77 (2014) 6
- J Med Chem 51: 3905-12 (2008) 5
- J Med Chem 36: 3533-41 (1994) 5
- J Med Chem 40: 1230-46 (1997) 5
- Bioorg Med Chem 17: 8174-85 (2009) 5
- J Med Chem 43: 2514-22 (2000) 5
- J Med Chem 46: 2216-26 (2003) 5
- Bioorg Med Chem 15: 886-96 (2007) 5
- J Med Chem 49: 1925-31 (2006) 5
- J Med Chem 33: 3190-8 (1990) 5
- Bioorg Med Chem Lett 2: 821-826 (1992) 5
- Bioorg Med Chem Lett 18: 614-8 (2008) 5
- Bioorg Med Chem Lett 8: 1991-6 (1999) 5
- Bioorg Med Chem Lett 14: 1845-8 (2004) 5
- J Med Chem 38: 2188-95 (1995) 5
- J Med Chem 44: 4563-76 (2001) 5
- Bioorg Med Chem Lett 24: 3255-9 (2014) 5
- J Med Chem 60: 9239-9250 (2017) 4
- J Med Chem 40: 4265-80 (1998) 4
- J Pharmacol Exp Ther 303: 29-35 (2002) 4
- J Med Chem 61: 3712-3725 (2018) 4
- J Med Chem 41: 2524-36 (1998) 4
- J Med Chem 34: 3164-71 (1991) 3
- J Pharmacol Exp Ther 279: 1335-44 (1996) 3
- J Med Chem 31: 164-8 (1988) 3
- J Pharmacol Exp Ther 312: 619-26 (2005) 3
- J Med Chem 42: 1999-2006 (1999) 3
- Bioorg Med Chem Lett 8: 2897-902 (1999) 3
- Bioorg Med Chem 16: 3049-58 (2008) 3
- Bioorg Med Chem 19: 1048-54 (2011) 3
- J Med Chem 46: 4273-86 (2003) 2
- Mol Pharmacol 54: 322-33 (1998) 2
- J Pharmacol Exp Ther 284: 500-7 (1998) 2
- J Med Chem 35: 1102-8 (1992) 2
- Mol Pharmacol 64: 865-75 (2003) 2
- J Med Chem 55: 2125-43 (2012) 2
- J Pharmacol Exp Ther 240: 51-8 (1987) 2
- J Med Chem 29: 1004-9 (1986) 2
- J Med Chem 35: 15-27 (1992) 2
- J Med Chem 35: 3141-7 (1992) 2
- J Med Chem 35: 2274-83 (1992) 2
- J Med Chem 35: 2184-91 (1992) 2
- J Med Chem 35: 3270-9 (1992) 2
- Bioorg Med Chem Lett 1: 147-150 (1991) 2
- J Med Chem 37: 4085-99 (1995) 2
- Bioorg Med Chem Lett 23: 6481-5 (2013) 2
- ...
Institutions 32▿
- Universit£ 45
- Niddk 42
- National Institutes of Health 22
- National Institute Of Diabetes And Digestive And Kidney Diseases 14
- The University Of Toledo 12
- TBA 9
- Georgetown University 9
- University of California 7
- Novo Nordisk 6
- University Of North Carolina At Chapel Hill 5
- American Cyanamid 5
- Georgetown University School Of Medicine 5
- National Institute of Diabetes and Digestive and Kidney Diseases 5
- Research Triangle Institute 5
- Royal Danish School of Pharmacy 5
- Medical Research Division Of American Cyanamid 5
- Parke-Davis Pharmaceutical Research 5
- Smithkline Beecham Pharmaceuticals 4
- University of Arkansas 4
- Warner-Lambert 4
- University of Arizona 4
- Targacept 3
- University Of Wuerzburg 3
- University Of California 3
- University Of South Carolina 2
- Sandoz Pharma 2
- University of Uppsala 2
- Novo Nordisk Cns Division 2
- University of South Carolina 2
- The Danish University of Pharmaceutical Sciences 2
- University Of Strasburg 2
- H. Lundbeck 2
- ...
Affinity: 0.40 to 1.0E+6 nM▿
- Ki 163
- IC50 40
- Kd 3
- EC50 73
- Affinity ≤ nM
Xtal structures: 0
Docked structures: 0
Catalog Cmpds: 1