BDBM411840 US10392391, Compound I-N-275::US10787452, Compound I-N-275::US11117900, Compound I-N-275::US11370798, Cmpd. # I-N-275::US20230271963, Compound I-N-275

SMILES CC(=O)N1CCN(CC1)c1c(F)cncc1NC(=O)c1c(N)nn2cc(F)cnc12

InChI Key InChIKey=AEGXKBZODBYKQN-UHFFFAOYSA-N

Data  10 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 411840   

TargetSerine/threonine-protein kinase ATR(Homo sapiens (Human))
Vertex Pharmaceuticals

US Patent
LigandPNGBDBM411840(US10392391, Compound I-N-275 | US10787452, Compoun...)
Affinity DataKi: <10nMAssay Description:Assays were carried out at 25° C. in the presence of 5 nM full-length ATR. An assay stock buffer solution was prepared containing all of the reagents...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetSerine/threonine-protein kinase ATR(Homo sapiens (Human))
Vertex Pharmaceuticals

US Patent
LigandPNGBDBM411840(US10392391, Compound I-N-275 | US10787452, Compoun...)
Affinity DataKi:  505nMAssay Description:Assays were carried out at 25° C. in the presence of 5 nM full-length ATR. An assay stock buffer solution was prepared containing all of the reagents...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent