BDBM224013 8-Mercaptoquinoline (8TQ)::US10005735, Example 8TQ

SMILES Sc1cccc2cccnc12

InChI Key InChIKey=MHTSJSRDFXZFHQ-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 224013   

Target26S proteasome non-ATPase regulatory subunit 14(Homo sapiens (Human))
California Institute of Technology

LigandPNGBDBM224013(8-Mercaptoquinoline (8TQ) | US10005735, Example 8T...)
Affinity DataIC50:  2.40E+3nMpH: 7.5 T: 2°CAssay Description:Fluorescence polarization assays were performed in low-volume 384-well solid black plates (Molecular Devices) in quadruplicate. The assays were perfo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target26S proteasome non-ATPase regulatory subunit 14(Homo sapiens (Human))
California Institute of Technology

LigandPNGBDBM224013(8-Mercaptoquinoline (8TQ) | US10005735, Example 8T...)
Affinity DataIC50:  2.80E+3nMAssay Description:In brief, this Rpn11 bioassay employs a fluorescent polarization readout based on the ability of the 26S proteasome to cleave the protein substrate i...More data for this Ligand-Target Pair
In DepthDetails US Patent
Target26S proteasome non-ATPase regulatory subunit 14(Homo sapiens (Human))
California Institute of Technology

LigandPNGBDBM224013(8-Mercaptoquinoline (8TQ) | US10005735, Example 8T...)
Affinity DataIC50:  2.50E+3nMAssay Description:Inhibition of 26S proteasome regulatory subunit RPN11 deubiquitinating activity in human erythrocytes using Ub4-pepOG protein substrate preincubated ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed