BDBM22869 6-chloro-10-(4-methylpiperazin-1-yl)-2,9-diazatricyclo[9.4.0.0^{3,8}]pentadeca-1,3(8),4,6,10,12,14-heptaene::CLOZARIL::Clozapine::Leponex::US10259786, Clozapine

SMILES CN1CCN(CC1)C1=c2ccccc2=Nc2ccc(Cl)cc2N1

InChI Key InChIKey=ZUXABONWMNSFBN-UHFFFAOYSA-N

Data  408 KI  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 22869   

Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Case Western Reserve University

Curated by PDSP Ki Database
LigandPNGBDBM22869(6-chloro-10-(4-methylpiperazin-1-yl)-2,9-diazatric...)
Affinity DataKi:  105nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Case Western Reserve University

Curated by PDSP Ki Database
LigandPNGBDBM22869(6-chloro-10-(4-methylpiperazin-1-yl)-2,9-diazatric...)
Affinity DataKi:  140nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Case Western Reserve University

Curated by PDSP Ki Database
LigandPNGBDBM22869(6-chloro-10-(4-methylpiperazin-1-yl)-2,9-diazatric...)
Affinity DataKi:  143nM ΔG°:  -9.33kcal/moleT: 2°CAssay Description:All assays were incubated in a total volume of 200 mL in 96-well microtiter plates for 1 h at 37 °C, except for 5-HT1ARs which were incubated at room...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Case Western Reserve University

Curated by PDSP Ki Database
LigandPNGBDBM22869(6-chloro-10-(4-methylpiperazin-1-yl)-2,9-diazatric...)
Affinity DataKi:  143nM ΔG°:  -9.33kcal/moleT: 2°CAssay Description:The composition of the assay buffers was as follows: for 5-HT1AR: 50 mM Tris¿HCl, 0.1 mM EDTA, 4 mM MgCl2, 10 lM pargyline, and 0.1% ascorbate; for 5...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Case Western Reserve University

Curated by PDSP Ki Database
LigandPNGBDBM22869(6-chloro-10-(4-methylpiperazin-1-yl)-2,9-diazatric...)
Affinity DataKi:  145nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Case Western Reserve University

Curated by PDSP Ki Database
LigandPNGBDBM22869(6-chloro-10-(4-methylpiperazin-1-yl)-2,9-diazatric...)
Affinity DataKi:  160nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM22869(6-chloro-10-(4-methylpiperazin-1-yl)-2,9-diazatric...)
Affinity DataKi:  180nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM22869(6-chloro-10-(4-methylpiperazin-1-yl)-2,9-diazatric...)
Affinity DataKi:  710nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM22869(6-chloro-10-(4-methylpiperazin-1-yl)-2,9-diazatric...)
Affinity DataKi:  1.39E+3nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM22869(6-chloro-10-(4-methylpiperazin-1-yl)-2,9-diazatric...)
Affinity DataKi:  1.70E+3nMMore data for this Ligand-Target Pair
In DepthDetails PubMed