BDBM379760 US9926281, Compound 220::US9926281, Compound 425

SMILES CC1(CC(CO)C(=O)N2CCN(CC2)c2cc(Cl)cc(Cl)c2)NC(=O)NC1=O

InChI Key InChIKey=LHKXLEZLEFHFJV-UHFFFAOYSA-N

Data  15 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 379760   

Target72 kDa type IV collagenase(Homo sapiens (Human))
Galapagos

US Patent
LigandPNGBDBM379760(US9926281, Compound 220 | US9926281, Compound 425)
Affinity DataIC50: >2.00E+4nMAssay Description:MMP2: Protocol 2: The basis for the assay is the cleavage of the substrate 390 MMP FRET substrate I (Anaspec, Catalog n#: AS-27076) by human MMP2 (R&...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Target72 kDa type IV collagenase(Homo sapiens (Human))
Galapagos

US Patent
LigandPNGBDBM379760(US9926281, Compound 220 | US9926281, Compound 425)
Affinity DataIC50:  2.82E+3nMAssay Description:MMP2: Protocol 2: The basis for the assay is the cleavage of the substrate 390 MMP FRET substrate I (Anaspec, Catalog n#: AS-27076) by human MMP2 (R&...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Target72 kDa type IV collagenase(Homo sapiens (Human))
Galapagos

US Patent
LigandPNGBDBM379760(US9926281, Compound 220 | US9926281, Compound 425)
Affinity DataIC50:  2.80E+3nMAssay Description:Inhibition of human recombinant MMP2 (AA34 to 660) assessed as cleavage of fluorescent substrate using 390 MMP FRET as substrate incubated for 30 min...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed