BDBM50573682 CHEMBL4872886

SMILES CC(C)C[C@@H](N)C(=O)Nc1ccc(-c2cnco2)c(OC(F)F)c1

InChI Key InChIKey=GCTFTMWXZFLTRR-GFCCVEGCSA-N

Data  20 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50573682   

TargetAP2-associated protein kinase 1(Homo sapiens (Human))
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50573682(CHEMBL4872886)
Affinity DataIC50:  12nMAssay Description:Inhibition of recombinant GST-Xa-tagged human AAK1 (30 to 330 residues) using 5-FAM-labelled Alla-KEEQSQITSQVTGQIGWR-NH2 peptide as substrate incubat...More data for this Ligand-Target Pair
TargetAP2-associated protein kinase 1(Homo sapiens (Human))
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50573682(CHEMBL4872886)
Affinity DataIC50:  12nMAssay Description:Inhibition of bacterially expressed GST-Xa-tagged human AAK1 using 5-FAM-labelled Aha-KEEQSQITSQVTGQIGWR-NH2 peptide as substrate incubated for 3 hrs...More data for this Ligand-Target Pair
TargetAP2-associated protein kinase 1(Homo sapiens (Human))
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50573682(CHEMBL4872886)
Affinity DataIC50:  12nMAssay Description:Inhibition of recombinant human GST-Xa-tagged-AAK1 (30 to 330 residues) using (5-FAM)-Aha-KEEQSQITSQVTGQIGWR-NH2 as substrate incubated for 3 hrs in ...More data for this Ligand-Target Pair
TargetAP2-associated protein kinase 1(Homo sapiens (Human))
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50573682(CHEMBL4872886)
Affinity DataIC50:  51nMAssay Description:Inhibition of full length human AAK1 expressed in HEK293F incubated for 3 hrs by Western blot analysisMore data for this Ligand-Target Pair
TargetAP2-associated protein kinase 1(Homo sapiens (Human))
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50573682(CHEMBL4872886)
Affinity DataIC50:  51nMAssay Description:Inhibition of human AAK1 expressed in HEK293 cells assessed as suppression of AP2 phosphorylation measured after 3 hrs by Western blot analysisMore data for this Ligand-Target Pair