BDBM50331728 CHEMBL1289316::N-(2-((3S,4S)-1-(cis-4-(benzo[d][1,3]dioxol-5-yl)-4-hydroxycyclohexyl)-4-ethoxypyrrolidin-3-ylamino)-2-oxoethyl)-3-(trifluoromethyl)benzamide

SMILES CCO[C@H]1CN(C[C@@H]1NC(=O)CNC(=O)c1cccc(c1)C(F)(F)F)[C@H]1CC[C@](O)(CC1)c1ccc2OCOc2c1

InChI Key InChIKey=MZEOSVPWMSEFPW-UTWBDPIXSA-N

Data  9 IC50  4 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50331728   

TargetC-C motif chemokine 2(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50331728(CHEMBL1289316 | N-(2-((3S,4S)-1-(cis-4-(benzo[d][1...)
Affinity DataKd:  0.720nMAssay Description:Displacement of [3H]INCB3344 from human CCR2 receptor expressed in human U2OS cell membranes assessed as association and dissociation of compound by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C motif chemokine 2(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50331728(CHEMBL1289316 | N-(2-((3S,4S)-1-(cis-4-(benzo[d][1...)
Affinity DataKd:  0.900nMAssay Description:Displacement of [3H]INCB3344 from human CCR2 receptor expressed in human U2OS cell membranes by saturation binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C motif chemokine 2(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50331728(CHEMBL1289316 | N-(2-((3S,4S)-1-(cis-4-(benzo[d][1...)
Affinity DataKd:  1.20nMAssay Description:Displacement of [3H]INCB3344 from human CCR2 receptor expressed in human U2OS cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C motif chemokine 2(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50331728(CHEMBL1289316 | N-(2-((3S,4S)-1-(cis-4-(benzo[d][1...)
Affinity DataKd:  0.230nMAssay Description:Displacement of [3H]INCB3344 from human CCR2 receptor expressed in human U2OS cell membranes assessed as association and dissociation of radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed