BindingDB BDBM5655 2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methylpiperidin-4-yl]-4H-chromen-4-one::CHEMBL428690::Flavopiridol::US10294218, Example Flavopiridol::US9617225, Flavopiridol

BDBM5655 2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methylpiperidin-4-yl]-4H-chromen-4-one::CHEMBL428690::Flavopiridol::US10294218, Example Flavopiridol::US9617225, Flavopiridol

SMILES CN1CC[C@@H]([C@H](O)C1)c1c(O)cc(O)c2c1oc(cc2=O)-c1ccccc1Cl

InChI Key InChIKey=BIIVYFLTOXDAOV-YVEFUNNKSA-N

Data 9 KI 151 IC50 782 Kd

PDB links: 5 PDB IDs match this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 5655

Cyclin-dependent kinase 6(Homo sapiens (Human))TBA

BDBM5655(2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydr...)

IC50: 80nMAssay Description:Inhibition of Homo sapiens (human) cyclin-dependent kinase 6More data for this Ligand-Target Pair

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Cyclin-dependent kinase 6(Homo sapiens (Human))TBA

BDBM5655(2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydr...)

IC50: 80nMAssay Description:Inhibition of CDK6 (unknown origin)More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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Cyclin-dependent kinase 6(Homo sapiens (Human))TBA

BDBM5655(2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydr...)

IC50: 60nMAssay Description:Inhibition of CDK6 (unknown origin)More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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Cyclin-dependent kinase 6(Homo sapiens (Human))TBA

BDBM5655(2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydr...)

IC50: 60nMAssay Description:Inhibition of CDK6 (unknown origin)More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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Cyclin-dependent kinase 6(Homo sapiens (Human))TBA

BDBM5655(2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydr...)

IC50: 20nMAssay Description:Inhibition of CDK6 (unknown origin)More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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Cyclin-dependent kinase 6(Homo sapiens (Human))TBA

BDBM5655(2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydr...)

IC50: 60nMAssay Description:In vitro antagonism of the 5-HT-3 receptor determined by inhibition of 5-HT-induced depolarization of the isolated rat vagus nerve.More data for this Ligand-Target Pair

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Filter my 942 hits

Targets 401▿
- Epidermal growth factor receptor 23
- Tyrosine-protein kinase ABL1 22
- Cyclin-dependent kinase 2 20
- Cyclin-dependent kinase 1 17
- Cyclin-dependent kinase 4 17
- Mast/stem cell growth factor receptor Kit 14
- Cyclin-dependent kinase 9 14
- Receptor-type tyrosine-protein kinase FLT3 12
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform 12
- Cyclin-T1/Cyclin-dependent kinase 9 12
- Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 12
- Cyclin-dependent kinase/G2/mitotic-specific cyclin- 1 11
- Cyclin-dependent kinase 2/G1/S-specific cyclin-E1 9
- Cyclin-A2/Cyclin-dependent kinase 2 7
- Cyclin-dependent kinase 5 7
- Proto-oncogene tyrosine-protein kinase receptor Ret 6
- Cyclin-dependent kinase 7 6
- Cyclin-dependent kinase 6 6
- Ribosomal protein S6 kinase alpha-2 5
- Glycogen synthase kinase-3 beta 5
- Ribosomal protein S6 kinase alpha-5 5
- Ribosomal protein S6 kinase alpha-1 4
- Dual specificity protein kinase CLK1 4
- Ephrin type-A receptor 6 4
- Hepatocyte growth factor receptor 4
- Mitogen-activated protein kinase 14 4
- Serine/threonine-protein kinase B-raf 4
- Ribosomal protein S6 kinase alpha-6 4
- Ribosomal protein S6 kinase alpha-4 4
- Fibroblast growth factor receptor 3 4
- Mitogen-activated protein kinase 3 3
- Cyclin-G-associated kinase 3
- Serine/threonine-protein kinase 17B 3
- Ephrin type-A receptor 5 3
- Death-associated protein kinase 3 3
- Dual specificity protein kinase CLK3 3
- Dual specificity protein kinase CLK2 3
- Tyrosine-protein kinase JAK1 3
- Serine/threonine-protein kinase pim-1 3
- Calcium/calmodulin-dependent protein kinase kinase 1 3
- Serine/threonine-protein kinase pim-2 3
- Calcium/calmodulin-dependent protein kinase kinase 2 3
- Cyclin-dependent kinase 16 3
- Phosphorylase b kinase gamma catalytic chain, liver/testis isoform 3
- Non-receptor tyrosine-protein kinase TYK2 3
- 5'-AMP-activated protein kinase catalytic subunit alpha-1 3
- Cyclin-dependent kinase 5 activator 1 3
- Glycogen synthase kinase-3 alpha 3
- Calcium/calmodulin-dependent protein kinase type II subunit beta 3
- Cyclin-dependent kinase 1/G2/mitotic-specific cyclin-B 3
- Serine/threonine-protein kinase PLK4 3
- MAP kinase-interacting serine/threonine-protein kinase 2 3
- Calcium/calmodulin-dependent protein kinase type II subunit alpha 3
- Ephrin type-B receptor 1 3
- Activated CDC42 kinase 1 3
- Proto-oncogene tyrosine-protein kinase Src 3
- Myosin light chain kinase, smooth muscle 3
- Tyrosine-protein kinase Tec 2
- BMP-2-inducible protein kinase 2
- Cyclin-dependent kinase 11B 2
- Cyclin-dependent kinase 11A 2
- LIM domain kinase 1 2
- LIM domain kinase 2 2
- ALK tyrosine kinase receptor 2
- NUAK family SNF1-like kinase 2 2
- Calcium/calmodulin-dependent protein kinase type 1 2
- NUAK family SNF1-like kinase 1 2
- AP2-associated protein kinase 1 2
- Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2
- Serine/threonine-protein kinase PAK 1 2
- Protein kinase C theta type 2
- Serine/threonine-protein kinase PAK 2 2
- Serine/threonine-protein kinase PAK 3 2
- Dual specificity mitogen-activated protein kinase kinase 2 2
- Serine/threonine-protein kinase PAK 4 2
- Phosphatidylinositol 5-phosphate 4-kinase type-2 beta 2
- Serine/threonine-protein kinase tousled-like 2 2
- Dual specificity mitogen-activated protein kinase kinase 3 2
- Serine/threonine-protein kinase PAK 5 2
- Serine/threonine-protein kinase PAK 6 2
- Serine/threonine-protein kinase tousled-like 1 2
- Tyrosine-protein kinase JAK3 2
- Tyrosine-protein kinase JAK2 2
- Dual specificity mitogen-activated protein kinase kinase 1 2
- Dual specificity mitogen-activated protein kinase kinase 6 2
- Dual specificity mitogen-activated protein kinase kinase 4 2
- Leucine-rich repeat serine/threonine-protein kinase 2 2
- Tyrosine-protein kinase ZAP-70 2
- Casein kinase I isoform gamma-3 2
- Casein kinase I isoform gamma-2 2
- Casein kinase I isoform epsilon 2
- Casein kinase I isoform gamma-1 2
- Ephrin type-A receptor 1 2
- Ephrin type-A receptor 3 2
- Ephrin type-A receptor 2 2
- Tyrosine-protein kinase BTK 2
- Ephrin type-A receptor 4 2
- Tyrosine-protein kinase receptor UFO 2
- Insulin-like growth factor 1 receptor 2
- Activin receptor type-1 2
- Myosin light chain kinase 2, skeletal/cardiac muscle 2
- Tyrosine-protein kinase Srms 2
- Wee1-like protein kinase 2
- Ankyrin repeat and protein kinase domain-containing protein 1 2
- Tyrosine-protein kinase Lyn 2
- Focal adhesion kinase 1 2
- Tyrosine-protein kinase TXK 2
- Ephrin type-A receptor 8 2
- Death-associated protein kinase 2 2
- Death-associated protein kinase 1 2
- Serine/threonine-protein kinase D2 2
- Serine/threonine-protein kinase D3 2
- TGF-beta receptor type-2 2
- Serine/threonine-protein kinase D1 2
- Dual specificity tyrosine-phosphorylation-regulated kinase 1B 2
- Dual specificity tyrosine-phosphorylation-regulated kinase 1A 2
- O94806/P05129/P05771/P17252/P24723/P41743/Q02156/Q04759/Q05513/Q05655/Q15139 2
- Cyclin-dependent kinase 8 2
- Serine/threonine-protein kinase pim-3 2
- Cyclin-dependent kinase 3 2
- Serine/threonine-protein kinase 36 2
- Testis-specific serine/threonine-protein kinase 1 2
- Protein kinase C epsilon type 2
- Cyclin-dependent kinase 17 2
- Bone morphogenetic protein receptor type-2 2
- Cyclin-dependent kinase 19 2
- Protein-tyrosine kinase 6 2
- Casein kinase II subunit alpha 2
- Cyclin-dependent kinase 14 2
- Leukocyte tyrosine kinase receptor 2
- Cytoplasmic tyrosine-protein kinase BMX 2
- Tyrosine-protein kinase ABL2 2
- Atypical kinase COQ8B, mitochondrial 2
- cGMP-dependent protein kinase 2 2
- cGMP-dependent protein kinase 1 2
- Serine/threonine-protein kinase SIK2 2
- Tyrosine-protein kinase Fes/Fps 2
- Serine/threonine-protein kinase SIK1 2
- 3-phosphoinositide-dependent protein kinase 1 2
- Mitogen-activated protein kinase 1 2
- Serine/threonine-protein kinase 3 2
- Discoidin domain-containing receptor 2 2
- Mitogen-activated protein kinase 4 2
- Serine/threonine-protein kinase 4 2
- Mitogen-activated protein kinase 9 2
- SRSF protein kinase 2 2
- Mitogen-activated protein kinase 6 2
- Mitogen-activated protein kinase 7 2
- Mitogen-activated protein kinase 8 2
- Calcium/calmodulin-dependent protein kinase type IV 2
- Tyrosine-protein kinase SYK 2
- Serine/threonine-protein kinase RIO1 2
- Serine/threonine-protein kinase LATS1 2
- Serine/threonine-protein kinase RIO3 2
- Serine/threonine-protein kinase 32B 2
- Serine/threonine-protein kinase 32C 2
- Vascular endothelial growth factor receptor 2 2
- Insulin receptor 2
- Tyrosine-protein kinase HCK 2
- Vascular endothelial growth factor receptor 3 2
- Vascular endothelial growth factor receptor 1 2
- Serine/threonine-protein kinase PLK1 2
- Insulin receptor-related protein 2
- Serine/threonine-protein kinase PLK3 2
- Tyrosine-protein kinase receptor TYRO3 2
- Serine/threonine-protein kinase BRSK1 2
- Serine/threonine-protein kinase LATS2 2
- cAMP-dependent protein kinase catalytic subunit alpha 2
- Citron Rho-interacting kinase 2
- Platelet-derived growth factor receptor alpha 2
- Serine/threonine-protein kinase BRSK2 2
- Serine/threonine-protein kinase Chk1 2
- cAMP-dependent protein kinase catalytic subunit PRKX 2
- SRSF protein kinase 1 2
- Tyrosine-protein kinase Yes 2
- Serine/threonine-protein kinase MRCK beta 2
- Serine/threonine-protein kinase MRCK gamma 2
- Casein kinase II subunit alpha' 2
- Serine/threonine-protein kinase STK11 2
- Tyrosine-protein kinase FRK 2
- Receptor tyrosine-protein kinase erbB-2 2
- Cyclin-dependent kinase 1/G2/mitotic-specific cyclin-B1/G2/mitotic-specific cyclin-B2/G2/mitotic-specific cyclin-B3 2
- Serine/threonine-protein kinase Nek9 2
- Serine/threonine-protein kinase Nek7 2
- Serine/threonine-protein kinase Nek6 2
- Serine/threonine-protein kinase Nek5 2
- Serine/threonine-protein kinase Nek2 2
- Serine/threonine-protein kinase Nek1 2
- Serine/threonine-protein kinase receptor R3 2
- MAP/microtubule affinity-regulating kinase 3 2
- MAP kinase-interacting serine/threonine-protein kinase 1 2
- Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase 2
- MAP/microtubule affinity-regulating kinase 4 2
- Serine/threonine-protein kinase 10 2
- Serine/threonine-protein kinase 38-like 2
- Dual specificity protein kinase TTK 2
- Myosin-IIIb 2
- Myosin-IIIa 2
- Tyrosine-protein kinase ITK/TSK 2
- Myotonin-protein kinase 2
- Protein kinase C eta type 2
- Bone morphogenetic protein receptor type-1A 2
- Receptor-interacting serine/threonine-protein kinase 1 2
- Tyrosine-protein kinase Blk 2
- Receptor-interacting serine/threonine-protein kinase 2 2
- Serine/threonine-protein kinase 16 2
- Non-receptor tyrosine-protein kinase TNK1 2
- Inhibitor of nuclear factor kappa-B kinase subunit epsilon 2
- Serine/threonine-protein kinase NLK 2
- Casein kinase I isoform delta 2
- Cyclin-dependent kinase 18 [3-474] 2
- RAF proto-oncogene serine/threonine-protein kinase 2
- Serine/threonine-protein kinase 26 2
- Serine/threonine-protein kinase 24 2
- Dual specificity testis-specific protein kinase 1 2
- Serine/threonine-protein kinase 25 2
- Ephrin type-B receptor 3 2
- Serine/threonine-protein kinase 33 2
- Ephrin type-B receptor 4 2
- Ephrin type-B receptor 2 2
- MAP kinase-activated protein kinase 2 2
- Platelet-derived growth factor receptor beta 2
- Epithelial discoidin domain-containing receptor 1 2
- MAP kinase-activated protein kinase 5 2
- Muscle, skeletal receptor tyrosine-protein kinase 2
- Tyrosine-protein kinase Fer 2
- 5'-AMP-activated protein kinase catalytic subunit alpha-2 2
- Tyrosine-protein kinase receptor Tie-1 2
- Calcium/calmodulin-dependent protein kinase type II subunit delta 2
- Proto-oncogene tyrosine-protein kinase ROS 2
- Serine/threonine-protein kinase DCLK1 2
- Serine/threonine-protein kinase DCLK2 2
- Cyclin-A1/Cyclin-A2/Cyclin-dependent kinase 2 2
- Serine/threonine-protein kinase DCLK3 2
- Angiopoietin-1 receptor 2
- Serine/threonine-protein kinase TNNI3K 2
- Interferon-induced, double-stranded RNA-activated protein kinase 2
- Mitogen-activated protein kinase kinase kinase kinase 3 2
- Mitogen-activated protein kinase kinase kinase kinase 1 2
- Serine/threonine-protein kinase MRCK alpha 2
- Casein kinase I isoform alpha-like 2
- Mitogen-activated protein kinase kinase kinase kinase 4 2
- Mitogen-activated protein kinase kinase kinase kinase 5 2
- Mitogen-activated protein kinase 15 2
- Activin receptor type-1B 2
- Myosin light chain kinase family member 4 2
- Mitogen-activated protein kinase kinase kinase 9 2
- RAC-gamma serine/threonine-protein kinase 2
- Mitogen-activated protein kinase kinase kinase 5 2
- Interleukin-1 receptor-associated kinase 3 2
- Mitogen-activated protein kinase kinase kinase 4 2
- RAC-alpha serine/threonine-protein kinase 2
- Activin receptor type-2B 2
- Activin receptor type-2A 2
- BDNF/NT-3 growth factors receptor 2
- Serine/threonine-protein kinase 17A 2
- Tyrosine-protein kinase Lck 2
- Protein kinase C delta type 2
- NT-3 growth factor receptor 2
- Dual specificity protein kinase CLK4 2
- Protein-tyrosine kinase 2-beta 2
- High affinity nerve growth factor receptor 2
- Tyrosine-protein kinase Mer 2
- Serine/threonine-protein kinase N2 2
- Calcium/calmodulin-dependent protein kinase type II subunit gamma 2
- cAMP-dependent protein kinase catalytic subunit beta 2
- Serine/threonine-protein kinase N1 2
- Ribosomal protein S6 kinase alpha-3 2
- Calcium/calmodulin-dependent protein kinase type 1D 2
- STE20-like serine/threonine-protein kinase 2
- Calcium/calmodulin-dependent protein kinase type 1G 2
- Fibroblast growth factor receptor 4 2
- Glycogen phosphorylase, muscle form 2
- Tyrosine-protein kinase Fgr 2
- Aurora kinase B 2
- Mitogen-activated protein kinase kinase kinase 20 2
- Fibroblast growth factor receptor 1 2
- Aurora kinase A 2
- Fibroblast growth factor receptor 2 2
- Atypical kinase COQ8A, mitochondrial 2
- Aurora kinase C 2
- Mitogen-activated protein kinase 12 2
- Mitogen-activated protein kinase 11 2
- Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha 2
- RAC-beta serine/threonine-protein kinase 2
- Mitogen-activated protein kinase 10 2
- Tyrosine-protein kinase Fyn 2
- Tyrosine-protein kinase CSK 2
- Macrophage colony-stimulating factor 1 receptor 2
- eIF-2-alpha kinase GCN2 2
- Maternal embryonic leucine zipper kinase 2
- Serine/threonine-protein kinase MARK1 2
- Serine/threonine-protein kinase MARK2 2
- TRAF2 and NCK-interacting protein kinase 2
- Mitogen-activated protein kinase kinase kinase 10 2
- Mitogen-activated protein kinase kinase kinase 11 2
- Peripheral plasma membrane protein CASK 1
- Tubulin alpha-1A chain 1
- Receptor tyrosine-protein kinase erbB-4 1
- Rhodopsin kinase GRK1 1
- Uncharacterized serine/threonine-protein kinase SBK3 1
- Receptor tyrosine-protein kinase erbB-3 1
- cAMP-dependent protein kinase catalytic subunit alpha/beta/gamma 1
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform 1
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform 1
- Protein kinase C iota type 1
- Transient receptor potential cation channel subfamily M member 6 1
- Serine/threonine-protein kinase Nek4 1
- Serine/threonine-protein kinase Nek3 1
- Macrophage-stimulating protein receptor 1
- Cyclin-dependent kinase-like 3 1
- Cyclin-dependent kinase-like 2 1
- Serine/threonine-protein kinase SIK3 [59-1321] 1
- Homeodomain-interacting protein kinase 4 1
- La-related protein 7 1
- Homeodomain-interacting protein kinase 3 1
- Cyclin-dependent kinase-like 5 1
- Dual specificity mitogen-activated protein kinase kinase 7 1
- Dual specificity mitogen-activated protein kinase kinase 5 1
- Cyclin-dependent kinase 6/G1/S-specific cyclin-D3 1
- Serine/threonine-protein kinase Sgk3 1
- Myosin light chain kinase 3 1
- Serine/threonine-protein kinase Nek11 1
- Serine/threonine-protein kinase mTOR 1
- Eukaryotic translation initiation factor 2-alpha kinase 1 1
- Bone morphogenetic protein receptor type-1B 1
- SNF-related serine/threonine-protein kinase 1
- Homeodomain-interacting protein kinase 2 1
- Homeodomain-interacting protein kinase 1 1
- Receptor-interacting serine/threonine-protein kinase 4 1
- Ribosomal protein S6 kinase beta-1 1
- Serine/threonine-protein kinase OSR1 1
- Serine/threonine-protein kinase MAK 1
- Serine/threonine-protein kinase/endoribonuclease IRE1 1
- Phosphatidylinositol 3-kinase C2 domain-containing subunit gamma 1
- Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma 1
- Serine/threonine-protein kinase SBK1 1
- Ephrin type-B receptor 6 1
- Rhodopsin kinase GRK7 1
- STE20/SPS1-related proline-alanine-rich protein kinase 1
- Phosphatidylinositol 4-kinase beta 1
- Calcium-dependent protein kinase 1 1
- Dual serine/threonine and tyrosine protein kinase 1
- Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma 1
- Serine/threonine-protein kinase TAO1 1
- Serine/threonine-protein kinase PknB 1
- Serine/threonine-protein kinase 38 1
- Serine/threonine-protein kinase TAO3 1
- Serine/threonine-protein kinase 35 1
- Serine/threonine-protein kinase PRP4 homolog 1
- Serine/threonine-protein kinase TAO2 1
- Mitogen-activated protein kinase kinase kinase kinase 2 1
- Cyclin-dependent kinase-like 1 [2-358] 1
- Cyclin-dependent kinase 2 homolog 1
- Cyclin-dependent kinase 12 1
- Cyclin-dependent kinase 13 1
- Cyclin-dependent kinase 15 1
- Interleukin-1 receptor-associated kinase 4 1
- Cyclin-dependent kinase 5 activator 1 [99-307] 1
- Serine/threonine-protein kinase VRK2 1
- Mitogen-activated protein kinase kinase kinase 6 1
- Interleukin-1 receptor-associated kinase 1 1
- Mitogen-activated protein kinase kinase kinase 7 1
- Mitogen-activated protein kinase kinase kinase 2 1
- Mitogen-activated protein kinase kinase kinase 1 1
- Mitogen-activated protein kinase kinase kinase 3 1
- Serine/threonine-protein kinase ICK 1
- Microtubule-associated serine/threonine-protein kinase 1 1
- Megakaryocyte-associated tyrosine-protein kinase 1
- Cyclin homolog/dependent kinase 6 1
- Rho-associated protein kinase 2 1
- Bromodomain testis-specific protein 1
- Rho-associated protein kinase 1 1
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform 1
- Serine/threonine-protein kinase ULK1 1
- Serine/threonine-protein kinase ULK2 1
- Serine/threonine-protein kinase ULK3 1
- Mitogen-activated protein kinase kinase kinase 19 1
- CDK-activating kinase assembly factor MAT1/Cyclin-H/Cyclin-dependent kinase 7 1
- Mitogen-activated protein kinase kinase kinase 15 1
- SRSF protein kinase 3 1
- G protein-coupled receptor kinase 4 1
- Serine/threonine-protein kinase TBK1 1
- Hormonally up-regulated neu tumor-associated kinase 1
- Cyclin-H/Cyclin-dependent kinase 7 1
- Serine/threonine-protein kinase RIO2 1
- Serine/threonine-protein kinase 32A 1
- Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta 1
- Serine/threonine-protein kinase PLK2 1
- Inhibitor of nuclear factor kappa-B kinase subunit beta 1
- Serine/threonine-protein kinase NIM1 1
- Mitogen-activated protein kinase 13 1
- Inhibitor of nuclear factor kappa-B kinase subunit alpha 1
- Wee1-like protein kinase 2 1
- Casein kinase I isoform alpha 1
- Misshapen-like kinase 1 1
- Protein kinase C alpha type 1
- Serine/threonine-protein kinase Chk2 1
- Mitogen-activated protein kinase kinase kinase 12 1
- Mitogen-activated protein kinase kinase kinase 13 1
- Dual specificity tyrosine-phosphorylation-regulated kinase 2 1
- ...
Publications 47▿
- Nat Biotechnol 29: 1046-51 (2011) 442
- Nat Biotechnol 26: 127-32 (2008) 317
- Nat Biotechnol 23: 329-36 (2005) 22
- Bioorg Med Chem 27: 677-685 (2019) 15
- J Med Chem 59: 8667-8684 (2016) 9
- J Med Chem 63: 13228-13257 (2020) 7
- Eur J Med Chem 183: (2019) 7
- J Med Chem 56: 660-70 (2013) 5
- Eur J Med Chem 172: 143-153 (2019) 5
- Eur J Med Chem 199: (2020) 5
- Eur J Med Chem 240: (2022) 4
- Bioorg Med Chem Lett 10: 1037-41 (2000) 4
- J Med Chem 65: 893-921 (2022) 4
- J Med Chem 65: 935-954 (2022) 4
- Nat Chem Biol 4: 357-65 (2008) 4
- J Med Chem 48: 737-43 (2005) 4
- Eur J Med Chem 142: 424-458 (2017) 4
- J Nat Prod 79: 616-28 (2016) 3
- Bioorg Med Chem Lett 13: 1133-6 (2003) 3
- Bioorg Med Chem Lett 15: 1943-7 (2005) 3
- J Med Chem 43: 4126-34 (2000) 3
- J Med Chem 64: 12548-12571 (2021) 3
- J Med Chem 45: 1741-7 (2002) 3
- J Med Chem 57: 578-99 (2014) 3
- AAPS J 8: 204-21 (2006) 3
- J Med Chem 65: 6390-6418 (2022) 3
- Eur J Med Chem 215: (2021) 3
- J Med Chem 55: 2811-9 (2012) 3
- J Med Chem 46: 876-9 (2003) 2
- Medchemcomm 6: 444-454 (2015) 2
- J Med Chem 60: 9470-9489 (2017) 2
- RSC Med Chem 11: 611-624 (2020) 1
- Bioorg Med Chem 16: 7128-33 (2008) 1
- Eur J Med Chem 45: 4316-30 (2010) 1
- J Med Chem 63: 11934-11944 (2020) 1
- J Med Chem 47: 3537-45 (2004) 1
- Eur J Med Chem 46: 2043-57 (2011) 1
- Trends Pharmacol Sci 25: 471-80 (2004) 1
- J Med Chem 61: 1664-1687 (2018) 1
- US Patent US10294218 (2019) 1
- Bioorg Med Chem Lett 10: 1819-22 (2000) 1
- J Med Chem 48: 6843-54 (2005) 1
- US Patent US9617225 (2017) 1
- J Med Chem 55: 1287-95 (2012) 1
- J Med Chem 45: 3905-27 (2002) 1
- J Med Chem 57: 3939-65 (2014) 1
- Bioorg Med Chem 15: 702-13 (2006) 1
Institutions 40▿
- Ambit Biosciences 781
- China Pharmaceutical University 25
- University Of Nebraska Medical Center 9
- Tianjin University Of Science And Technology 7
- University Of Oxford 5
- University Paris-Saclay 5
- University Of Padova 5
- Centro De Investigaciones Biol�Gicas Margarita Salas (Csic) 4
- West China Hospital 4
- Csir-Indian Institute Of Integrative Medicine 4
- Bristol-Myers Squibb Pharmaceutical Research Institute 4
- Lawrence Berkeley National Laboratory 4
- Nerviano Medical Sciences Oncology 4
- Mitotix 4
- Central University Of Punjab 4
- Novartis Pharmaceuticals 3
- Bristol-Myers Squibb 3
- Shanghaitech University 3
- Eli Lilly 3
- Monash University (Parkville Campus) 3
- Icahn School Of Medicine At Mount Sinai 3
- Georgetown University 3
- The People'S Hospital Of Xinjiang Uyghur Autonomous Region 3
- Csir-Indian Institute of Integrative Medicine 3
- Institut De Chimie Des Substances Naturelles (Icsn) 3
- Martin-Luther-University Halle-Wittenberg 2
- Chinese Academy Of Medical Sciences And Peking Union Medical College 2
- Virostatics 2
- Universidad San Pablo Ceu 1
- Dalian University Of Technology 1
- Novo Nordisk 1
- University Of The Pacific 1
- Vichem Chemie 1
- Purdue University 1
- University Of Kansas 1
- University Of Jordan 1
- The Rockefeller University 1
- Universit£ 1
- Emory University School Of Medicine 1
- Korea Research Institute of Bioscience and Biotechnology 1
Affinity: 0.69 to 9.6E+5 nM▿
- Ki 9
- IC50 151
- Kd 782
- Affinity ≤ nM
Xtal structures: 1
Docked structures: 3
Catalog Cmpds: 1