BDBM50257064 CHEMBL2386850
SMILES Cc1cc(Oc2cncnc2)cc(n1)C(=O)Nc1ccc(F)cn1
InChI Key InChIKey=RBAHIIPVJVMACF-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 4 hits for monomerid = 50257064
TargetCytochrome P450 3A4(Homo sapiens (Human))
Vanderbilt University Institute of Imaging Science
Curated by ChEMBL
Vanderbilt University Institute of Imaging Science
Curated by ChEMBL
Affinity DataIC50: >2.00E+5nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using testosterone as substrate preincubated for 15 mins measured after 8 mins in presence or absence ...More data for this Ligand-Target Pair
TargetCytochrome P450 3A4(Homo sapiens (Human))
Vanderbilt University Institute of Imaging Science
Curated by ChEMBL
Vanderbilt University Institute of Imaging Science
Curated by ChEMBL
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate in presence of NADPH by LC/MS/MS analysisMore data for this Ligand-Target Pair
TargetCytochrome P450 3A4(Homo sapiens (Human))
Vanderbilt University Institute of Imaging Science
Curated by ChEMBL
Vanderbilt University Institute of Imaging Science
Curated by ChEMBL
Affinity DataIC50: 1.33E+5nMAssay Description:Negative allosteric modulation of rat mGlu5 receptor expressed in HEK293A cells assessed as inhibition of glutamate induced-calcium mobilization prei...More data for this Ligand-Target Pair
TargetCytochrome P450 3A4(Homo sapiens (Human))
Vanderbilt University Institute of Imaging Science
Curated by ChEMBL
Vanderbilt University Institute of Imaging Science
Curated by ChEMBL
Affinity DataIC50: >3.00E+4nMAssay Description:Negative allosteric modulation of rat mGlu5 receptor expressed in HEK293A cells assessed as inhibition of glutamate induced-calcium mobilization prei...More data for this Ligand-Target Pair