BDBM100152 7-methoxy-1-methyl-9H-beta-carboline;hydrochloride::7-methoxy-1-methyl-9H-pyrido[3,4-b]indole;hydrochloride::HARMINE::Harmine hydrochloride::MLS002153910::SMR001233259::cid_5359389

SMILES COc1ccc2c(c1)[nH]c1c(C)nccc21

InChI Key InChIKey=BXNJHAXVSOCGBA-UHFFFAOYSA-N

Data  33 KI  155 IC50  5 Kd  1 EC50

PDB links: 5 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 100152   

TargetDual specificity protein kinase CLK1(Homo sapiens (Human))
Saarland University

Curated by ChEMBL
LigandPNGBDBM100152(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)
Affinity DataIC50:  220nMAssay Description:Inhibition of recombinant human GST-tagged CLK1 catalytic domain (129 to 484 residues) expressed in Escherichia coli using GRSRSRSRSRSRSRSR as substr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein kinase CLK1(Homo sapiens (Human))
Saarland University

Curated by ChEMBL
LigandPNGBDBM100152(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)
Affinity DataIC50:  26nMAssay Description:Inhibition of human recombinant CLK1-GST expressed in Escherichia coli using GRSRSRSRSRSR as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein kinase CLK1(Mus musculus)
Cnrs

Curated by ChEMBL
LigandPNGBDBM100152(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)
Affinity DataIC50:  72nMAssay Description:Inhibition of mouse recombinant GST-tagged CLK1 expressed in Escherichia coli using GRSRSRSRSRSR as substrate and [gamma33P]ATP after 30 mins by scin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein kinase CLK1(Homo sapiens (Human))
Saarland University

Curated by ChEMBL
LigandPNGBDBM100152(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)
Affinity DataIC50:  26nMAssay Description:Inhibition of GST-tagged human recombinant CLK1 expressed in Escherichia coli using RS peptide as substrate incubated for 30 mins in presence of [gam...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein kinase CLK1(Homo sapiens (Human))
Saarland University

Curated by ChEMBL
LigandPNGBDBM100152(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)
Affinity DataIC50:  72nMAssay Description:Inhibition of CLK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein kinase CLK1(Homo sapiens (Human))
Saarland University

Curated by ChEMBL
LigandPNGBDBM100152(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)
Affinity DataIC50:  242nMAssay Description:Inhibition of recombinant human CLK1 expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric scinti...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetDual specificity protein kinase CLK1(Homo sapiens (Human))
Saarland University

Curated by ChEMBL
LigandPNGBDBM100152(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)
Affinity DataIC50:  299nMAssay Description:Inhibition of recombinant human CLK1 expressed in Sf9 insect cells using myelin basic protein as substrate incubated for 110 mins in presence of ATP ...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetDual specificity protein kinase CLK1(Homo sapiens (Human))
Saarland University

Curated by ChEMBL
LigandPNGBDBM100152(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)
Affinity DataKd:  12nMAssay Description:Binding affinity to human CLK1 assessed as equilibrium dissociation constant measured upto 240 min by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails PubMed