BDBM161389 US10124003, Ref. Ex. Compound 3::US10835536, Ex. Comp 2::US10894048, Ex Comp 2::US9108973, 2

SMILES COc1cc(OC)cc(c1)C#Cc1nn([C@H]2CCN(C2)C(=O)C=C)c2ncnc(N)c12

InChI Key InChIKey=KEIPNCCJPRMIAX-HNNXBMFYSA-N

Data  33 IC50

PDB links: 3 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 161389   

TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Taiho Pharmaceutical

US Patent
LigandPNGBDBM161389(US10124003, Ref. Ex. Compound 3 | US10835536, Ex. ...)
Affinity DataIC50:  3.60nMAssay Description:Purified recombinant human FGFR4 protein was purchased from Carna Biosciences, Inc. When setting conditions for the measurement of the inhibitory ef...More data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Taiho Pharmaceutical

US Patent
LigandPNGBDBM161389(US10124003, Ref. Ex. Compound 3 | US10835536, Ex. ...)
Affinity DataIC50:  3.60nMAssay Description:When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR1 kinase activity, a biotinylated peptide (biotin-EEPLYW...More data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Taiho Pharmaceutical

US Patent
LigandPNGBDBM161389(US10124003, Ref. Ex. Compound 3 | US10835536, Ex. ...)
Affinity DataIC50:  2.20nMAssay Description:Inhibition of human FGFR1 (459 to 765 residues) expressed in Escherichia coli BL21 (DE3) by HTRF assayMore data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Taiho Pharmaceutical

US Patent
LigandPNGBDBM161389(US10124003, Ref. Ex. Compound 3 | US10835536, Ex. ...)
Affinity DataIC50:  3.90nMAssay Description:Inhibition of FGFR1 (unknown origin)More data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Taiho Pharmaceutical

US Patent
LigandPNGBDBM161389(US10124003, Ref. Ex. Compound 3 | US10835536, Ex. ...)
Affinity DataIC50:  3.90nMAssay Description:Inhibition of human recombinant FGFR1 expressed in Escherichia coli BL21 DE3 assessed as inhibition by western blot analysisMore data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Taiho Pharmaceutical

US Patent
LigandPNGBDBM161389(US10124003, Ref. Ex. Compound 3 | US10835536, Ex. ...)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of human FGFR1More data for this Ligand-Target Pair