BDBM238159 US10017502, Example 4b::US9394291, 4a

SMILES CNC(=O)C[C@H]1COc2cc(F)ccc2N1C(=O)c1ccc2OCC(=O)Nc2c1

InChI Key InChIKey=MBKYLPOPYYLTNW-ZDUSSCGKSA-N

Data  2 KI  7 IC50  1 EC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 238159   

TargetMineralocorticoid receptor(Homo sapiens (Human))
Pharmaron-Beijing

Curated by ChEMBL
LigandPNGBDBM238159(US10017502, Example 4b | US9394291, 4a)
Affinity DataKi:  40nMAssay Description:Displacement of [3H]-aldosterone to human mineralocorticoid receptor LBD by radiometric binding assayMore data for this Ligand-Target Pair
TargetMineralocorticoid receptor(Homo sapiens (Human))
Pharmaron-Beijing

Curated by ChEMBL
LigandPNGBDBM238159(US10017502, Example 4b | US9394291, 4a)
Affinity DataEC50:  13nMAssay Description:Modulation activity at human mineralocorticoid receptor in human EA.hy926 cells assessed as induction of nuclear translocation of mineralocorticoid r...More data for this Ligand-Target Pair
TargetMineralocorticoid receptor(Homo sapiens (Human))
Pharmaron-Beijing

Curated by ChEMBL
LigandPNGBDBM238159(US10017502, Example 4b | US9394291, 4a)
Affinity DataIC50:  316nMAssay Description:Antagonist activity at full length human mineralocorticoid receptor expressed in human U2OS cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
TargetMineralocorticoid receptor(RAT)
Pharmaron-Beijing

Curated by ChEMBL
LigandPNGBDBM238159(US10017502, Example 4b | US9394291, 4a)
Affinity DataIC50:  79nMAssay Description:Antagonist activity at gal4-fused rat mineralocorticoid receptor LBD in expressed in human U2OS cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
TargetMineralocorticoid receptor(Homo sapiens (Human))
Pharmaron-Beijing

Curated by ChEMBL
LigandPNGBDBM238159(US10017502, Example 4b | US9394291, 4a)
Affinity DataIC50: <1.00E+4nMAssay Description:Modulation activity at human mineralocorticoid receptor in human EA.hy926 cells assessed as blocking of nuclear translocation of mineralocorticoid re...More data for this Ligand-Target Pair
TargetMineralocorticoid receptor(Homo sapiens (Human))
Pharmaron-Beijing

Curated by ChEMBL
LigandPNGBDBM238159(US10017502, Example 4b | US9394291, 4a)
Affinity DataIC50:  398nMAssay Description:Antagonist activity at gal4-fused human mineralocorticoid receptor LBD expressed in UAS-MR-bla HEK293 cells by luciferase reporter gene assayMore data for this Ligand-Target Pair