BDBM50038649 2-(6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizin-5-yl)acetic acid::CHEMBL300982::Licofelone::ML-3000::[2-(4-Chloro-phenyl)-6,6-dimethyl-1-phenyl-6,7-dihydro-5H-pyrrolizin-3-yl]-acetic acid::[6-(4-CHLOROPHENYL)-2,2-DIMETHYL-7-PHENYL-2,3-DIHYDRO-1H-PYRROLIZIN-5-YL]ACETIC ACID
SMILES CC1(C)Cc2c(c(c(CC(O)=O)n2C1)-c1ccc(Cl)cc1)-c1ccccc1
InChI Key InChIKey=UAWXGRJVZSAUSZ-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 9 hits for monomerid = 50038649
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Organon Laboratories
Curated by ChEMBL
Organon Laboratories
Curated by ChEMBL
Affinity DataIC50: 210nMAssay Description:Inhibition constant against arachidonate 5-lipoxygenase More data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Organon Laboratories
Curated by ChEMBL
Organon Laboratories
Curated by ChEMBL
Affinity DataIC50: 180nMAssay Description:Inhibition of human recombinant 5-LOX expressed in Escherichia coli BL2-DE3 incubated 10 mins before substrate addition by fluorescence spectrophotom...More data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
Peking University
Curated by ChEMBL
Peking University
Curated by ChEMBL
Affinity DataIC50: 3.60E+3nMAssay Description:Inhibition of 5-LOX in rat RBL1 cells assessed as reduction in LTB4 productionMore data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Organon Laboratories
Curated by ChEMBL
Organon Laboratories
Curated by ChEMBL
Affinity DataIC50: 180nMAssay Description:Inhibition of 5-LOX (unknown origin) by ELISAMore data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Organon Laboratories
Curated by ChEMBL
Organon Laboratories
Curated by ChEMBL
Affinity DataIC50: 500nMAssay Description:Inhibition of human recombinant 5-LOX expressed in Escherichia coli BL21 assessed as decrease in 5-HPETE production preincubated with enzyme followed...More data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Organon Laboratories
Curated by ChEMBL
Organon Laboratories
Curated by ChEMBL
Affinity DataIC50: 510nMAssay Description:Inhibition of 5-LOX (unknown origin) using arachidonic acid as substrate preincubated for 5 mins followed by substrate addition and measured after 10...More data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Organon Laboratories
Curated by ChEMBL
Organon Laboratories
Curated by ChEMBL
Affinity DataIC50: 180nMAssay Description:Inhibition of 5-LOX (unknown origin)More data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Organon Laboratories
Curated by ChEMBL
Organon Laboratories
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant human 5-LO expressed in Escherichia coli JM109 using arachidonic acid as substrate incubated for 10 mins by HPLC analysisMore data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Organon Laboratories
Curated by ChEMBL
Organon Laboratories
Curated by ChEMBL
Affinity DataIC50: 230nMAssay Description:Inhibition of human 5-lipoxygenase in human cellsMore data for this Ligand-Target Pair