BDBM50459007 CHEMBL4218734

SMILES COCc1ccc(cn1)-c1ccc2ncc(C(N)=O)c(N[C@@H](C)C3CCOCC3)c2c1

InChI Key InChIKey=DISRGUXSEDBDDN-HNNXBMFYSA-N

Data  17 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50459007   

TargetSerine-protein kinase ATM(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50459007(CHEMBL4218734)
Affinity DataIC50:  46nMAssay Description:Competitive inhibition of ATM (unknown origin) measured by ATP-competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSerine-protein kinase ATM(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50459007(CHEMBL4218734)
Affinity DataIC50: <1.20nMAssay Description:Inhibition of ATM (unknown origin) using p53 as substrate incubated for 30 mins followed by substrate addition measured after 2 hrs in presence of AT...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine-protein kinase ATM(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50459007(CHEMBL4218734)
Affinity DataIC50:  46nMAssay Description:Inhibition of ATM phosphorylation at Ser-1981 residue in human HT-29 cells incubated for 1 hr followed by X-ray irradiation by Hoechst staining based...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine-protein kinase ATM(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50459007(CHEMBL4218734)
Affinity DataIC50:  46nMAssay Description:Inhibition of ATM autophosphorylation at Ser1981 residue in human HT-29 cells measured after 1 hr by Hoechst staining based fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed