BDBM50058759 CHEMBL436559::CHEMBL462831::Cariporide::N-(4-Isopropyl-3-methanesulfonyl-benzoyl)-guanidine (Cariporide)::N-(4-Isopropyl-3-methanesulfonyl-benzoyl)-guanidine(Cariporide)::N-(4-isopropyl-3-methanesulfonyl-benzoyl)-guanidine::N-(diaminomethylene)-4-isopropyl-3-(methylsulfonyl)benzamide

SMILES CC(C)c1ccc(cc1S(C)(=O)=O)C(=O)NC(N)=N

InChI Key InChIKey=IWXNYAIICFKCTM-UHFFFAOYSA-N

Data  17 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50058759   

TargetSodium/hydrogen exchanger 2(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50058759(CHEMBL436559 | CHEMBL462831 | Cariporide | N-(4-Is...)
Affinity DataIC50:  6.20E+4nMAssay Description:Compound is screened in AP1 cells expressing human NHE-2 for sodium hydrogen exchange activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/hydrogen exchanger 2(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50058759(CHEMBL436559 | CHEMBL462831 | Cariporide | N-(4-Is...)
Affinity DataIC50:  6.20E+4nMAssay Description:Inhibition of human NHE2 expressed in Ap1 cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/hydrogen exchanger 2(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50058759(CHEMBL436559 | CHEMBL462831 | Cariporide | N-(4-Is...)
Affinity DataIC50:  2.87E+4nMAssay Description:In vitro concentration of compound required to inhibit NHE-2 mediated intracellular maximal pH recovery by 50%More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed