BDBM344324 US10251889, Example 33::US10758542, Example 33::US9782415, Example 33::US9796724, Example 33

SMILES OC(=O)[C@H]1CC[C@@H](CC1)NC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F

InChI Key InChIKey=DBAVNXWRJILFRQ-AKCHCHLHSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 344324   

TargetTyrosine-protein kinase JAK2 [808-1132](Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM344324(US10251889, Example 33 | US10758542, Example 33 | ...)
Affinity DataIC50:  23.4nMAssay Description:Jak2: Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mix...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2 [808-1132](Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM344324(US10251889, Example 33 | US10758542, Example 33 | ...)
Affinity DataIC50:  23.4nMAssay Description:Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent