BDBM28661 2-{2-methyl-4-[({4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}methyl)sulfanyl]phenoxy}acetic acid::CHEMBL38943::GW 501516::GW-501516::GW1516::GW501516
SMILES Cc1nc(sc1CSc1ccc(OCC(O)=O)c(C)c1)-c1ccc(cc1)C(F)(F)F
InChI Key InChIKey=YDBLKRPLXZNVNB-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 89 hits for monomerid = 28661
TargetPeroxisome proliferator-activated receptor delta(Homo sapiens (Human))
Sahmyook University
Curated by ChEMBL
Sahmyook University
Curated by ChEMBL
Affinity DataIC50: 5nM EC50: 3nMpH: 7.0 T: 2°CAssay Description:Competition-binding curves for test compounds were determined with expressed human PPAR LBD. Plots of inhibitor concentration versus cpm of radioliga...More data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataEC50: 1.89E+3nMAssay Description:The ligand binding domain for PPAR was fused to the yeast transcription factor GAL4 DNA binding domain. CV-1 cells were transiently transfected with ...More data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor delta(Homo sapiens (Human))
Sahmyook University
Curated by ChEMBL
Sahmyook University
Curated by ChEMBL
Affinity DataEC50: 1nMAssay Description:The ligand binding domain for PPAR was fused to the yeast transcription factor GAL4 DNA binding domain. CV-1 cells were transiently transfected with ...More data for this Ligand-Target Pair
Affinity DataEC50: 8.90E+3nMAssay Description:The ligand binding domain for PPAR was fused to the yeast transcription factor GAL4 DNA binding domain. CV-1 cells were transiently transfected with ...More data for this Ligand-Target Pair
Affinity DataEC50: 1.10E+3nMAssay Description:The HEK293 cells were co-transfected with DNA constructs containing the ligand-binding domain of PPAR and Gal4-luciferase reporter. The luciferase ac...More data for this Ligand-Target Pair
Affinity DataEC50: 850nMAssay Description:The HEK293 cells were co-transfected with DNA constructs containing the ligand-binding domain of PPAR and Gal4-luciferase reporter. The luciferase ac...More data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor delta(Homo sapiens (Human))
Sahmyook University
Curated by ChEMBL
Sahmyook University
Curated by ChEMBL
Affinity DataEC50: 1nMAssay Description:The confluent HEK293 cells were co-transfected with DNA construct containing PPARdelta-Gal4 chimeric receptor and Gal4-luciferase reporter. The lucif...More data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor delta(Homo sapiens (Human))
Sahmyook University
Curated by ChEMBL
Sahmyook University
Curated by ChEMBL
Affinity DataEC50: 1nMAssay Description:Maximum transcriptional activation of human PPAR delta receptorMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor delta(Homo sapiens (Human))
Sahmyook University
Curated by ChEMBL
Sahmyook University
Curated by ChEMBL
Affinity DataEC50: 3.20nMAssay Description:Partial agonist activity at human PPARdelta expressed in african green monkey CV1 cells transfected with Gal4 assessed as beta-galactosidase activity...More data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Mus musculus)
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataEC50: 1.00E+3nMAssay Description:Activity against murine PPAR gamma receptorMore data for this Ligand-Target Pair
Affinity DataEC50: 850nMAssay Description:Maximum transcriptional activation of human PPAR gamma receptorMore data for this Ligand-Target Pair
Affinity DataEC50: 1.10E+3nMAssay Description:Maximum transcriptional activation of human PPAR alpha receptorMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor alpha(Mus musculus)
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataEC50: 2.50E+3nMAssay Description:Activity against murine PPAR alpha receptorMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor delta(Mus musculus)
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataEC50: 20nMAssay Description:Activity against murine PPAR delta receptorMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor delta(Homo sapiens (Human))
Sahmyook University
Curated by ChEMBL
Sahmyook University
Curated by ChEMBL
Affinity DataEC50: 0.180nMAssay Description:Agonist activity at human PPARbeta expressed in HEK293 cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor delta(Homo sapiens (Human))
Sahmyook University
Curated by ChEMBL
Sahmyook University
Curated by ChEMBL
Affinity DataEC50: 0.5nMAssay Description:Agonist activity at pSG5-Gal4-tagged human PPAR-beta/delta ligand binding domain expressed in COS1 cells assessed as receptor activation incubated fo...More data for this Ligand-Target Pair
Affinity DataEC50: 1.23E+3nMAssay Description:Agonist activity at PPARalpha by transactivation assayMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor delta(Homo sapiens (Human))
Sahmyook University
Curated by ChEMBL
Sahmyook University
Curated by ChEMBL
Affinity DataEC50: 3nMAssay Description:Agonist activity at PPARdelta by transactivation assayMore data for this Ligand-Target Pair
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at PPARgamma by transactivation assayMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor delta(Homo sapiens (Human))
Sahmyook University
Curated by ChEMBL
Sahmyook University
Curated by ChEMBL
Affinity DataEC50: 1nMAssay Description:Activity at PPARbeta/delta by luciferase reporter gene transactivation assay in COS7 cellsMore data for this Ligand-Target Pair
Affinity DataEC50: 1.00E+4nMAssay Description:Activity at PPARalpha by luciferase reporter gene transactivation assay in COS7 cellsMore data for this Ligand-Target Pair
Affinity DataEC50: 1.00E+4nMAssay Description:Activity at PPARgamma by luciferase reporter gene transactivation assay in COS7 cellsMore data for this Ligand-Target Pair
Affinity DataEC50: >1.00E+4nMAssay Description:Activity at human adipose tissue PPAR gamma expressed in HEK293 cells by PPAR-GAL4 transactivation assayMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor delta(Homo sapiens (Human))
Sahmyook University
Curated by ChEMBL
Sahmyook University
Curated by ChEMBL
Affinity DataEC50: 7.90nMAssay Description:Activity at human placenta PPAR delta expressed in HEK293 cells by PPAR-GAL4 transactivation assayMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor delta(Mus musculus)
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataEC50: 54nMAssay Description:Agonist activity at mouse PPAR delta expressed in HEK293 cells by PPAR-GAL4 transactivation assayMore data for this Ligand-Target Pair
Affinity DataEC50: 3.90E+3nMAssay Description:Activity at human liver PPAR alpha expressed in HEK293 cells by PPAR-GAL4 transactivation assayMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor delta(Homo sapiens (Human))
Sahmyook University
Curated by ChEMBL
Sahmyook University
Curated by ChEMBL
Affinity DataEC50: 85nMAssay Description:Agonist activity at human PPARdelta receptor expressed in HEK293 cells by GAL4 transactivation assayMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor delta(Homo sapiens (Human))
Sahmyook University
Curated by ChEMBL
Sahmyook University
Curated by ChEMBL
Affinity DataEC50: 1.80nMAssay Description:Effect on PPARdelta transactivation activity in HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataEC50: 1.00E+3nMAssay Description:Effect on PPARalpha transactivation activity in HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataEC50: 8.60E+3nMAssay Description:Effect on PPARgamma transactivation activity in HEK293 cellsMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor delta(Homo sapiens (Human))
Sahmyook University
Curated by ChEMBL
Sahmyook University
Curated by ChEMBL
Affinity DataEC50: 4nMAssay Description:Agonist activity at human PPARdelta in HepG2 cells by GAL4-luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at human PPARgamma by transactivation assayMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor delta(Homo sapiens (Human))
Sahmyook University
Curated by ChEMBL
Sahmyook University
Curated by ChEMBL
Affinity DataEC50: 8nMAssay Description:Agonist activity at human PPARdelta by transactivation assayMore data for this Ligand-Target Pair
Affinity DataEC50: 3.90E+3nMAssay Description:Agonist activity at human PPARalpha by transactivation assayMore data for this Ligand-Target Pair
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at PPARalpha ligand binding domain expressed in human HeLa cells cotransfected with Gal4-DBD assessed as transcriptional activation ...More data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor delta(Homo sapiens (Human))
Sahmyook University
Curated by ChEMBL
Sahmyook University
Curated by ChEMBL
Affinity DataEC50: 8nMAssay Description:Agonist activity at PPARdelta ligand binding domain expressed in human HeLa cells cotransfected with Gal4-DBD assessed as transcriptional activation ...More data for this Ligand-Target Pair
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at PPARgamma ligand binding domain expressed in human HeLa cells cotransfected with Gal4-DBD assessed as transcriptional activation ...More data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor delta(Homo sapiens (Human))
Sahmyook University
Curated by ChEMBL
Sahmyook University
Curated by ChEMBL
Affinity DataEC50: 6nMAssay Description:Agonist activity at human PPARdelta ligand binding domain by FRET assayMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor delta(Mus musculus)
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataEC50: 77nMAssay Description:Agonist activity at mouse PPARdelta by FRET assayMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor delta(Homo sapiens (Human))
Sahmyook University
Curated by ChEMBL
Sahmyook University
Curated by ChEMBL
Affinity DataEC50: 5nMAssay Description:Agonist activity at human PPARdelta ligand binding domain expressed in human 293T cells cotransfected with Gal4-DBD by luciferase transactivation ass...More data for this Ligand-Target Pair
Affinity DataEC50: 1.10E+3nMAssay Description:Agonist activity at human PPARalpha expressed in HepG2 cells cotransfected with PPRE3-TK-luc assessed as beta-galactosidase activity after 20 to 22 h...More data for this Ligand-Target Pair
Affinity DataEC50: 800nMAssay Description:Agonist activity at human PPARgamma expressed in HepG2 cells cotransfected with PPRE3-TK-luc assessed as beta-galactosidase activity after 20 to 22 h...More data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor delta(Homo sapiens (Human))
Sahmyook University
Curated by ChEMBL
Sahmyook University
Curated by ChEMBL
Affinity DataEC50: 1.20nMAssay Description:Agonist activity at human PPARdelta expressed in HepG2 cells cotransfected with PPRE3-TK-luc assessed as beta-galactosidase activity after 20 to 22 h...More data for this Ligand-Target Pair
Affinity DataEC50: 4.10E+3nMAssay Description:Transactivation of GAL4-fused human PPARgamma DNA binding domain expressed in african green monkey CV1 cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 990nMAssay Description:Transactivation of GAL4-fused human PPARalpha DNA binding domain expressed in african green monkey CV1 cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor delta(Homo sapiens (Human))
Sahmyook University
Curated by ChEMBL
Sahmyook University
Curated by ChEMBL
Affinity DataEC50: 1.70nMAssay Description:Transactivation of GAL4-fused human PPARdelta DNA binding domain expressed in african green monkey CV1 cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor delta(Homo sapiens (Human))
Sahmyook University
Curated by ChEMBL
Sahmyook University
Curated by ChEMBL
Affinity DataEC50: 2nMAssay Description:Agonist activity at GAL4-fused human PPARdelta DNA binding domain expressed in HEK293 cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 990nMAssay Description:Agonist activity at human PPARalpha-LBD expressed in CV1 cells cotransfected with Gal4 after 40 hrs by luciferase based transactivation assayMore data for this Ligand-Target Pair
Affinity DataEC50: 4.10E+3nMAssay Description:Agonist activity at human PPARgamma-LBD expressed in CV1 cells cotransfected with Gal4 after 40 hrs by luciferase based transactivation assayMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor delta(Homo sapiens (Human))
Sahmyook University
Curated by ChEMBL
Sahmyook University
Curated by ChEMBL
Affinity DataEC50: 1.70nMAssay Description:Agonist activity at human PPARdelta-LBD expressed in CV1 cells cotransfected with Gal4 after 40 hrs by luciferase based transactivation assayMore data for this Ligand-Target Pair