BDBM50231520 (R)-N-[(S)-1-(4-carbamimidoyl-benzylcarbamoyl)-2-hydroxy-ethyl]-3-hydroxy-2-phenylmethanesulfonylamino-propionamide::CHEMBL252937::N-(BENZYLSULFONYL)SERYL-N~1~-{4-[(Z)-AMINO(IMINO)METHYL]BENZYL}SERINAMIDE::US8476306, 6.12

SMILES NC(=N)c1ccc(CNC(=O)[C@H](CO)NC(=O)[C@@H](CO)NS(=O)(=O)Cc2ccccc2)cc1

InChI Key InChIKey=ZNOKJHWJKULOGM-ZWKOTPCHSA-N

Data  6 KI  1 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50231520   

TargetUrokinase-type plasminogen activator(Human)
University of Antwerp (Ua)

Curated by ChEMBL
LigandPNGBDBM50231520((R)-N-[(S)-1-(4-carbamimidoyl-benzylcarbamoyl)-2-h...)
Affinity DataKi:  20nMAssay Description:Inhibition of human uPAMore data for this Ligand-Target Pair
TargetSerine protease 1(Rat)
The Medicines

US Patent
LigandPNGBDBM50231520((R)-N-[(S)-1-(4-carbamimidoyl-benzylcarbamoyl)-2-h...)
Affinity DataKi:  22nM ΔG°:  -10.4kcal/moleT: 24°CAssay Description:Inhibition constant of the compound against TrypsinMore data for this Ligand-Target Pair
In DepthDetails US Patent

TargetUrokinase plasminogen activator surface receptor(Rat)
The Medicines

US Patent
LigandPNGBDBM50231520((R)-N-[(S)-1-(4-carbamimidoyl-benzylcarbamoyl)-2-h...)
Affinity DataKi:  25nM ΔG°:  -10.3kcal/moleT: 24°CAssay Description:Inhibition constant of the compound against Plasminogen activator urokinaseMore data for this Ligand-Target Pair
In DepthDetails US Patent

TargetTransmembrane protease serine 11D(Human)
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM50231520((R)-N-[(S)-1-(4-carbamimidoyl-benzylcarbamoyl)-2-h...)
Affinity DataKi:  78nMAssay Description:Inhibition of human recombinant airway trypsin-like protease HAT using D-cyclohexylalanine-Pro-Arg-AMC as substrate by fluorescence plate reader anal...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasminogen(Rat)
The Medicines

US Patent
LigandPNGBDBM50231520((R)-N-[(S)-1-(4-carbamimidoyl-benzylcarbamoyl)-2-h...)
Affinity DataKi:  750nM ΔG°:  -8.32kcal/moleT: 24°CAssay Description:Inhibition constant of the compound against PlasminMore data for this Ligand-Target Pair
In DepthDetails US Patent

TargetProthrombin(Rat)
The Medicines

US Patent
LigandPNGBDBM50231520((R)-N-[(S)-1-(4-carbamimidoyl-benzylcarbamoyl)-2-h...)
Affinity DataKi:  1.40E+4nM ΔG°:  -6.59kcal/moleT: 24°CAssay Description:Inhibition constant of the compound against ThrombinMore data for this Ligand-Target Pair
In DepthDetails US Patent