BDBM1140 (4R,5R,6R)-Tetrahydro-3,6-bis-(phenylmethyl)-1-(3-cyano-4-fluorophenylmethyl)-5-hydroxy-4-(2-phenylethyl)-2(1H)-pyrimidinone::5-{[(4R,5R,6R)-3,6-dibenzyl-5-hydroxy-2-oxo-4-(2-phenylethyl)-1,3-diazinan-1-yl]methyl}-2-fluorobenzonitrile::Tetrahydropyrimidinone deriv. 89

SMILES O[C@@H]1[C@@H](CCc2ccccc2)N(Cc2ccccc2)C(=O)N(Cc2ccc(F)c(c2)C#N)[C@@H]1Cc1ccccc1

InChI Key InChIKey=DGXSQEWJDPUAGM-WRVRXEDSSA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 1140   

TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Dupont Pharmaceuticals

LigandPNGBDBM1140((4R,5R,6R)-Tetrahydro-3,6-bis-(phenylmethyl)-1-(3-...)
Affinity DataKi:  40nMAssay Description:Inhibition of HIV protease was measured by assay of the cleavage of a fluorescent peptide substrate. The fluorescent product (2-aminobenzoyl-Ala-Thr-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Dupont Pharmaceuticals

LigandPNGBDBM1140((4R,5R,6R)-Tetrahydro-3,6-bis-(phenylmethyl)-1-(3-...)
Affinity DataKi:  40nMAssay Description:Inhibition constant of HIV protease inhibitorsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Dupont Pharmaceuticals

LigandPNGBDBM1140((4R,5R,6R)-Tetrahydro-3,6-bis-(phenylmethyl)-1-(3-...)
Affinity DataKi:  40nMAssay Description:Inhibitory activity against HIV-1 proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Dupont Pharmaceuticals

LigandPNGBDBM1140((4R,5R,6R)-Tetrahydro-3,6-bis-(phenylmethyl)-1-(3-...)
Affinity DataKi:  40nMAssay Description:Inhibitory activity of compound against HIV-1 aspartyl protease.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed