BDBM15005 3-(4-{4-aminofuro[2,3-d]pyrimidin-5-yl}phenyl)-1-(3-phenoxyphenyl)urea::4-amino-5-diarylurea-furo[2,3-d]pyrimidine 8c

SMILES Nc1ncnc2occ(-c3ccc(NC(=O)Nc4cccc(Oc5ccccc5)c4)cc3)c12

InChI Key InChIKey=LUGSOVQEJNEDMV-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 15005   

TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM15005(3-(4-{4-aminofuro[2,3-d]pyrimidin-5-yl}phenyl)-1-(...)
Affinity DataIC50:  1.74E+3nMpH: 7.5 T: 2°CAssay Description:The assay uses purified GST-Tie-2 or GST-6x His-VEGFR2 interacting with biotinylated peptide substrates. HTRF is based on the proximity of europium c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiopoietin-1 receptor(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM15005(3-(4-{4-aminofuro[2,3-d]pyrimidin-5-yl}phenyl)-1-(...)
Affinity DataIC50:  407nMpH: 7.4 T: 2°CAssay Description:The assay uses purified GST-Tie-2 or GST-6x His-VEGFR2 interacting with biotinylated peptide substrates. HTRF is based on the proximity of europium c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed