BDBM17786 (4S)-4-(2-amino-6-phenoxy-3,4-dihydroquinazolin-3-yl)-N,4-dicyclohexyl-N-methylbutanamide::2-aminoquinazoline, 3a
SMILES CN(C1CCCCC1)C(=O)CC[C@@H](C1CCCCC1)N1Cc2cc(Oc3ccccc3)ccc2N=C1N
InChI Key InChIKey=JKQCQYBXDQPJNC-LJAQVGFWSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 6 hits for monomerid = 17786
Affinity DataKi: 8nMAssay Description:Inhibition of human BACE1More data for this Ligand-Target Pair
Affinity DataKi: 11nM ΔG°: -10.7kcal/molepH: 5.0 T: 2°CAssay Description:BACE-1 activity was measured at pH 5 using the FS1 FRET substrate. Compounds were preincubated with recombinant BACE-1 for 20 min before adding subst...More data for this Ligand-Target Pair
Affinity DataKi: 25nMAssay Description:Inhibition of recombinant beta-secretase 1More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Evotec
Curated by ChEMBL
Evotec
Curated by ChEMBL
Affinity DataIC50: 110nMpH: 4.0 T: 2°CAssay Description:Cathepsin D activity was measured at pH 4 using a FRET peptide substrate. Compounds were preincubated with recombinant human liver cathepsin D for 20...More data for this Ligand-Target Pair
Affinity DataIC50: 2.70E+3nMpH: 7.4 T: 2°CAssay Description:Renin activity was measured at pH 7.4 using a FRET peptide substrate. Compounds were added to recombinant human rennin and mixed before substrate was...More data for this Ligand-Target Pair