BDBM202363 US9238626, (+/-)-(Ib) HCl

SMILES CC1=CC2CC(C1)c1c(C2)nc2cc(Cl)ccc2c1NCCCCCCCCCNC(=O)c1cc(O)c2C(=O)c3c(O)cccc3C(=O)c2c1

InChI Key InChIKey=VZYCFKMNVCPCHV-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 202363   

TargetCholinesterase(Homo sapiens (Human))
Universitat De Barcelona

US Patent
LigandPNGBDBM202363(US9238626, (+/-)-(Ib) HCl)
Affinity DataIC50:  620nMpH: 8.0 T: 2°CAssay Description:BChE inhibitory activity determinations were carried out similarly by the method of Ellman et al., using 0.02 unit/mL of human serum BChE and 300 u...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
Universitat De Barcelona

US Patent
LigandPNGBDBM202363(US9238626, (+/-)-(Ib) HCl)
Affinity DataIC50:  120nMT: 2°CAssay Description:β-Secretase (BACE-1, Sigma) inhibition studies were performed by employing a peptide mimicking APP sequence as substrate (methoxycoumarin-Ser-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Universitat De Barcelona

US Patent
LigandPNGBDBM202363(US9238626, (+/-)-(Ib) HCl)
Affinity DataIC50:  32.6nMpH: 8.0 T: 2°CAssay Description:AChE inhibitory activity of compounds (Ia)-(Ie) and (-)-(Ib) and (+)-(Ib) was evaluated spectrophotometrically at 25° C. by the method of Ellma...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCholinesterase(Homo sapiens (Human))
Universitat De Barcelona

US Patent
LigandPNGBDBM202363(US9238626, (+/-)-(Ib) HCl)
Affinity DataIC50:  620nMAssay Description:Inhibition of human serum BChE using butyrylthiocholine iodide as a substrate preincubated for 20 mins followed by substrate addition by spectrophoto...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Universitat De Barcelona

US Patent
LigandPNGBDBM202363(US9238626, (+/-)-(Ib) HCl)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibition of human recombinant BACE-1 expressed in Escherichia coli using panvera peptide as a substrate incubated for 1 hr by fluorescence analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
University Of Barcelona

Curated by ChEMBL
LigandPNGBDBM202363(US9238626, (+/-)-(Ib) HCl)
Affinity DataIC50:  3.60nMAssay Description:Inhibition of human recombinant AChE using acetylthiocholine iodide as a substrate preincubated for 20 mins followed by substrate addition by spectro...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
University Of Barcelona

Curated by ChEMBL
LigandPNGBDBM202363(US9238626, (+/-)-(Ib) HCl)
Affinity DataIC50:  3.60nMpH: 8.0 T: 2°CAssay Description:AChE inhibitory activity of compounds (Ia)-(Ie) and (-)-(Ib) and (+)-(Ib) was evaluated spectrophotometrically at 25° C. by the method of Ellma...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent