BDBM21154 Isoxazole-based ligand, 5::N-{[3-(4-methoxyphenyl)-1,2-oxazol-5-yl]methyl}benzenesulfonamide

SMILES COc1ccc(cc1)-c1cc(CNS(=O)(=O)c2ccccc2)on1

InChI Key InChIKey=GHLQJCUCOQSQFJ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 21154   

TargetCytochrome P450 2C9(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM21154(Isoxazole-based ligand, 5 | N-{[3-(4-methoxyphenyl...)
Affinity DataIC50:  3.90E+4nMAssay Description:The inhibition of recombinant human CYP2C9 was measured as the ability to perform a demethylation of 7-methoxy-4-trifluoromethylcoumarin (MFC). Befor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM21154(Isoxazole-based ligand, 5 | N-{[3-(4-methoxyphenyl...)
Affinity DataIC50:  3.30E+4nMpH: 7.4 T: 2°CAssay Description:The inhibition of recombinant human CYP3A4 was measured as the ability to perform a debenzylation of 7-benzyloxy-4-trifluoromethylcoumarin (BFC). Bef...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed