BDBM212897 US9278960, 3-16::US9663506, Example 3-16

SMILES CC[C@@](O)(c1cn(Cc2ccc3c(cc(nc3c2)C(N)=O)-c2ccc(F)cn2)nn1)C(F)(F)F

InChI Key InChIKey=HPUYYHXUYOZNBL-OAQYLSRUSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 212897   

LigandPNGBDBM212897(US9278960, 3-16 | US9663506, Example 3-16)
Affinity DataIC50:  21nMAssay Description:The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM212897(US9278960, 3-16 | US9663506, Example 3-16)
Affinity DataIC50:  36nMAssay Description:Negative allosteric modulation of human mGluR2 by FLIPR assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM212897(US9278960, 3-16 | US9663506, Example 3-16)
Affinity DataIC50:  21nMAssay Description:The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent