BDBM217696 US9212182, 672
SMILES COc1cc(ccc1-n1c2ccc(cc2ccc1=O)S(=O)(=O)Nc1ncccn1)-c1cccc(c1)C(F)(F)F
InChI Key InChIKey=HSOCYPPAQYZHMJ-UHFFFAOYSA-N
Data 16 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 16 hits for monomerid = 217696
Affinity DataIC50: 23nMAssay Description:HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...More data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:Inhibition of human NaV1.7 expressed in HEK293 cells at -125 mV holding potential yielding 20 to 50% inactivation after 3 to 5 mins by PatchXpress au...More data for this Ligand-Target Pair
Affinity DataIC50: 30nMAssay Description:Inhibition of mouse Nav1.7 expressed in HEK293 cells measured after 3 to 5 mins by patchXpress electrophysiology assayMore data for this Ligand-Target Pair
Affinity DataIC50: 4.60E+3nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using diclofenac as substrate in presence of NADPHMore data for this Ligand-Target Pair
Affinity DataIC50: >4.25E+4nMAssay Description:Inhibition of human Nav1.4 expressed in HEK293 cells assessed as use-dependent block at pulse 26 after 3 to 8 mins by ionworks quattro electrophysiol...More data for this Ligand-Target Pair
Affinity DataIC50: >5.00E+4nMAssay Description:Reversible inhibition of CYP3A4 in human liver microsomes using midazolam as substrate in presence of NADPHMore data for this Ligand-Target Pair
Affinity DataIC50: >5.00E+4nMAssay Description:Time-dependent inhibition of CYP3A4 in human liver microsomes using midazolam as substrate preincubated with enzyme in presence of NADPH followed by ...More data for this Ligand-Target Pair
Affinity DataIC50: >3.00E+4nMAssay Description:Binding affinity towards estrogen receptor alpha by [3H]17-beta-estradiol displacement.More data for this Ligand-Target Pair
Affinity DataIC50: >4.25E+4nMAssay Description:Ability to activate estrogen receptor 1-mediated transcription.More data for this Ligand-Target Pair
Affinity DataIC50: >4.25E+4nMAssay Description:Ability to activate estrogen receptor 1-mediated transcription.More data for this Ligand-Target Pair
Affinity DataIC50: 6nMAssay Description:Ability to activate estrogen receptor 2-mediated transcription.More data for this Ligand-Target Pair
Affinity DataIC50: 6.60E+3nMAssay Description:Binding affinity towards estrogen receptor beta by [3H]17-beta-estradiol displacement.More data for this Ligand-Target Pair
Affinity DataIC50: 21nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293 cells at holding potential yielding 20 to 50% inactivation measured after 3 to 5 mins by patchXpress e...More data for this Ligand-Target Pair
Affinity DataIC50: >4.25E+4nMAssay Description:Inhibition of human Nav1.3 expressed in CHO cells assessed as use-dependent block at pulse 26 after 3 to 8 mins by ionworks quattro electrophysiology...More data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:Inhibition of slow inactivated human NaV1.7 expressed in HEK293 cells at -20 mV holding potential after 5 mins by IonWorks electrophysiology methodMore data for this Ligand-Target Pair
Affinity DataIC50: 650nMAssay Description:Inhibition of human Nav1.6 expressed in HEK293 cells assessed as use-dependent block at pulse 26 after 3 to 8 mins by ionworks quattro electrophysiol...More data for this Ligand-Target Pair