BDBM222657 US9315491, MTR-0457::US9801888, Compound MTR-0457

SMILES CSc1c(nc(nc1-c1cccnc1)-c1ccc(NC(=O)Nc2ccc(cc2)N2CCOCC2=O)cc1)N1CCOCC1

InChI Key InChIKey=OJIZSHHYITUGQM-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 222657   

TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Development Center For Biotechnology

US Patent
LigandPNGBDBM222657(US9315491, MTR-0457 | US9801888, Compound MTR-0457)
Affinity DataIC50:  5.80nMAssay Description:The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombinan...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Development Center For Biotechnology

US Patent
LigandPNGBDBM222657(US9315491, MTR-0457 | US9801888, Compound MTR-0457)
Affinity DataIC50:  5.80nMpH: 7.5Assay Description:The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent