BDBM22623 2-[(2S,4S)-4-fluoro-1-methylpyrrolidin-2-yl]-N-[(4-fluorophenyl)methyl]-5-hydroxy-1-methyl-6-oxo-1,6-dihydropyrimidine-4-carboxamide::N-Me-pyrimidone deriv., 22

SMILES CN1C[C@@H](F)C[C@H]1c1nc(C(=O)NCc2ccc(F)cc2)c(O)c(=O)n1C

InChI Key InChIKey=MBSMKNIEBKYDJI-STQMWFEESA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 22623   

TargetIntegrase(Human immunodeficiency virus 1)
Irbm-Mrl

Curated by ChEMBL
LigandPNGBDBM22623(2-[(2S,4S)-4-fluoro-1-methylpyrrolidin-2-yl]-N-[(4...)
Affinity DataIC50:  23nMAssay Description:Inhibition of HIV 1 recombinant integraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein(Human immunodeficiency virus type 1 group M subtyp...)
Irbm-Mrl

LigandPNGBDBM22623(2-[(2S,4S)-4-fluoro-1-methylpyrrolidin-2-yl]-N-[(4...)
Affinity DataIC50:  20nMpH: 7.8 T: 2°CAssay Description:The microtiter plate assay for stand transfer was performed with an immobilized donor substrate and a target substrate biotinylated at the 3-prime en...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed