BDBM263707 5-[4-[(3S)- 1-(3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-6-(4- methoxy- 2-methyl- phenyl)-8,9- dihydro- 7H- benzo[7]- annulen-2-ol1-fluoro-6- (2-fluoro-4- methyl- phenyl)-5- [4-[(3S)-1- (3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-8,9- dihydro- 7H- benzo[7]- annulen-2-ol::US9714221, Example 44
SMILES COc1ccc(c(C)c1)C1=C(c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c2ccc(O)cc2CCC1
InChI Key InChIKey=JDJNAPSFYSTLSF-NDEPHWFRSA-N
Data 7 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 7 hits for monomerid = 263707
Affinity DataIC50: 1nMpH: 7.4 T: 2°CAssay Description:It is a competition assay, where binding of a test compound to a complex comprised of (i) His6-ERα298-554 protein representing ERα ligand-b...More data for this Ligand-Target Pair
Affinity DataIC50: 16nMpH: 7.4 T: 2°CAssay Description:It is a competition assay, where binding of a test compound to a complex comprised of (i) His6-ERα298-554 protein representing ERα ligand-b...More data for this Ligand-Target Pair
Affinity DataIC50: 12nMpH: 7.4 T: 2°CAssay Description:It is a competition assay, where binding of a test compound to a complex comprised of (i) His6-ERα298-554 protein representing ERα ligand-b...More data for this Ligand-Target Pair
Affinity DataIC50: 12nMAssay Description:Beta-2 adrenergic receptor antagonistic activity on guinea pig tracheal chainsMore data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Antagonist activity at recombinant human His6-tagged ERalpha LBD (298 to 554 residues) expressed in Escherichia coli assessed as inhibition of estrad...More data for this Ligand-Target Pair
Affinity DataIC50: 0.200nMAssay Description:Induction of ERalpha degradation in human MCF7 cells after 4 hrs by in cell western assayMore data for this Ligand-Target Pair
Affinity DataIC50: 16nMAssay Description:Antagonist activity at recombinant human His6-tagged ERalpha LBD (298 to 554 residues) D538G mutant expressed in Escherichia coli assessed as inhibit...More data for this Ligand-Target Pair