BDBM265618 (5r,8r)-8-(((6-(2H-tetrazol-2-yl)pyridazin-3-yl)methyl)amino)-2-(4-methyl-5-oxo-2,5-dihydrofuran-3-yl)-2-azaspiro[4.5]decan-1-one::US9718808, 75

SMILES CC1=C(COC1=O)N1CC[C@@]2(CC[C@@H](CC2)NCc2ccc(nn2)-n2ncnn2)C1=O

InChI Key InChIKey=GYWPYIVIZPQBMD-OYOVHJISSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 265618   

TargetATP-sensitive inward rectifier potassium channel 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM265618((5r,8r)-8-(((6-(2H-tetrazol-2-yl)pyridazin-3-yl)me...)
Affinity DataIC50:  9.30nMAssay Description:A Thallium Flux Assay was performed on each of the final product compounds of the Examples. This assay has been described previously; see, e.g., PCT ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent