BDBM270588 (S)-6-(((2- chlorophenyl)(1-(1- cyanocyclopropyl)- 1H-1,2,3-triazol-4- yl)methyl-d)amino)- 4- (neopentylamino) quinazoline-8- carbonitrile::US10059695, I-20::US10577352, Compound I-20

SMILES CC(C)(C)CNc1ncnc2c(cc(NC(c3cn(nn3)C3(CC3)C#N)c3ccccc3Cl)cc12)C#N

InChI Key InChIKey=ILAHDUGQOPPNDT-UHFFFAOYSA-N

Data  2 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 270588   

TargetEpidermal growth factor receptor(Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM270588((S)-6-(((2- chlorophenyl)(1-(1- cyanocyclopropyl)-...)
Affinity DataIC50:  3.30nMpH: 7.0 T: 2°CAssay Description:EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM270588((S)-6-(((2- chlorophenyl)(1-(1- cyanocyclopropyl)-...)
Affinity DataEC50:  35nMAssay Description:EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM270588((S)-6-(((2- chlorophenyl)(1-(1- cyanocyclopropyl)-...)
Affinity DataIC50:  3.30nMAssay Description:EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM270588((S)-6-(((2- chlorophenyl)(1-(1- cyanocyclopropyl)-...)
Affinity DataEC50:  35nMpH: 7.0 T: 2°CAssay Description:EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent