BDBM278489 7-amino-3-(2,6-difluoro-3,5-dimethoxyphenyl)-8-(2-methoxyethoxy)-1-methyl-3,4-dihydro-pyrido[4,3-d]pyrimidin-2(1H)-one::US10040790, Example 5::US10450313, Example 5::US10947230, Example 5::US11530214, Example 5

SMILES COCCOc1c(N)ncc2CN(C(=O)N(C)c12)c1c(F)c(OC)cc(OC)c1F

InChI Key InChIKey=ZXZYUVSUMVHXPF-UHFFFAOYSA-N

Data  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 278489   

TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Incyte Holdings

US Patent
LigandPNGBDBM278489(7-amino-3-(2,6-difluoro-3,5-dimethoxyphenyl)-8-(2-...)
Affinity DataIC50: <100nMpH: 7.5Assay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFibroblast growth factor receptor 2(Homo sapiens (Human))
Incyte Holdings

US Patent
LigandPNGBDBM278489(7-amino-3-(2,6-difluoro-3,5-dimethoxyphenyl)-8-(2-...)
Affinity DataIC50: <100nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFibroblast growth factor receptor 3(Homo sapiens (Human))
Incyte Holdings

US Patent
LigandPNGBDBM278489(7-amino-3-(2,6-difluoro-3,5-dimethoxyphenyl)-8-(2-...)
Affinity DataIC50: <100nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Incyte Holdings

US Patent
LigandPNGBDBM278489(7-amino-3-(2,6-difluoro-3,5-dimethoxyphenyl)-8-(2-...)
Affinity DataIC50: <100nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFibroblast growth factor receptor 2(Homo sapiens (Human))
Incyte Holdings

US Patent
LigandPNGBDBM278489(7-amino-3-(2,6-difluoro-3,5-dimethoxyphenyl)-8-(2-...)
Affinity DataIC50: <100nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFibroblast growth factor receptor 3(Homo sapiens (Human))
Incyte Holdings

US Patent
LigandPNGBDBM278489(7-amino-3-(2,6-difluoro-3,5-dimethoxyphenyl)-8-(2-...)
Affinity DataIC50: <100nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Incyte Holdings

US Patent
LigandPNGBDBM278489(7-amino-3-(2,6-difluoro-3,5-dimethoxyphenyl)-8-(2-...)
Affinity DataIC50: <100nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFibroblast growth factor receptor 2(Homo sapiens (Human))
Incyte Holdings

US Patent
LigandPNGBDBM278489(7-amino-3-(2,6-difluoro-3,5-dimethoxyphenyl)-8-(2-...)
Affinity DataIC50: <100nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFibroblast growth factor receptor 3(Homo sapiens (Human))
Incyte Holdings

US Patent
LigandPNGBDBM278489(7-amino-3-(2,6-difluoro-3,5-dimethoxyphenyl)-8-(2-...)
Affinity DataIC50: <100nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Incyte Holdings

US Patent
LigandPNGBDBM278489(7-amino-3-(2,6-difluoro-3,5-dimethoxyphenyl)-8-(2-...)
Affinity DataIC50: <100nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFibroblast growth factor receptor 2(Homo sapiens (Human))
Incyte Holdings

US Patent
LigandPNGBDBM278489(7-amino-3-(2,6-difluoro-3,5-dimethoxyphenyl)-8-(2-...)
Affinity DataIC50: <100nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFibroblast growth factor receptor 3(Homo sapiens (Human))
Incyte Holdings

US Patent
LigandPNGBDBM278489(7-amino-3-(2,6-difluoro-3,5-dimethoxyphenyl)-8-(2-...)
Affinity DataIC50: <100nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent