BDBM278510 2'-(2,6-difluoro-3,5-dimethoxyphenyl)-6'-(tetrahydro-2H-pyran-4-ylamino)-1',2'-dihydro-3'H-spiro[cyclopropane-1,4'-[2,7]naphthyridin]-3'-one::US10040790, Example 26::US10450313, Example 26::US10947230, Example 26::US11530214, Example 26

SMILES COc1cc(OC)c(F)c(N2Cc3cnc(NC4CCOCC4)cc3C3(CC3)C2=O)c1F

InChI Key InChIKey=XCGLSKCGLBBYIN-UHFFFAOYSA-N

Data  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 278510   

TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Incyte Holdings

US Patent
LigandPNGBDBM278510(2'-(2,6-difluoro-3,5-dimethoxyphenyl)-6'-(tetrahyd...)
Affinity DataIC50: <100nMpH: 7.5Assay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFibroblast growth factor receptor 2(Homo sapiens (Human))
Incyte Holdings

US Patent
LigandPNGBDBM278510(2'-(2,6-difluoro-3,5-dimethoxyphenyl)-6'-(tetrahyd...)
Affinity DataIC50: <100nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFibroblast growth factor receptor 3(Homo sapiens (Human))
Incyte Holdings

US Patent
LigandPNGBDBM278510(2'-(2,6-difluoro-3,5-dimethoxyphenyl)-6'-(tetrahyd...)
Affinity DataIC50: <100nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Incyte Holdings

US Patent
LigandPNGBDBM278510(2'-(2,6-difluoro-3,5-dimethoxyphenyl)-6'-(tetrahyd...)
Affinity DataIC50: <100nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFibroblast growth factor receptor 2(Homo sapiens (Human))
Incyte Holdings

US Patent
LigandPNGBDBM278510(2'-(2,6-difluoro-3,5-dimethoxyphenyl)-6'-(tetrahyd...)
Affinity DataIC50: <100nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFibroblast growth factor receptor 3(Homo sapiens (Human))
Incyte Holdings

US Patent
LigandPNGBDBM278510(2'-(2,6-difluoro-3,5-dimethoxyphenyl)-6'-(tetrahyd...)
Affinity DataIC50: <100nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Incyte Holdings

US Patent
LigandPNGBDBM278510(2'-(2,6-difluoro-3,5-dimethoxyphenyl)-6'-(tetrahyd...)
Affinity DataIC50: <100nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFibroblast growth factor receptor 2(Homo sapiens (Human))
Incyte Holdings

US Patent
LigandPNGBDBM278510(2'-(2,6-difluoro-3,5-dimethoxyphenyl)-6'-(tetrahyd...)
Affinity DataIC50: <100nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFibroblast growth factor receptor 3(Homo sapiens (Human))
Incyte Holdings

US Patent
LigandPNGBDBM278510(2'-(2,6-difluoro-3,5-dimethoxyphenyl)-6'-(tetrahyd...)
Affinity DataIC50: <100nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Incyte Holdings

US Patent
LigandPNGBDBM278510(2'-(2,6-difluoro-3,5-dimethoxyphenyl)-6'-(tetrahyd...)
Affinity DataIC50: <100nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFibroblast growth factor receptor 2(Homo sapiens (Human))
Incyte Holdings

US Patent
LigandPNGBDBM278510(2'-(2,6-difluoro-3,5-dimethoxyphenyl)-6'-(tetrahyd...)
Affinity DataIC50: <100nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFibroblast growth factor receptor 3(Homo sapiens (Human))
Incyte Holdings

US Patent
LigandPNGBDBM278510(2'-(2,6-difluoro-3,5-dimethoxyphenyl)-6'-(tetrahyd...)
Affinity DataIC50: <100nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent