BDBM279088 5-(2-ethoxy-3-pyridyl)-3-methyl-1-[1-methylpropyl]-N-(1H-pyrazol-3-ylmethyl)pyrazolo[4,3-b]pyridin-7-amine,enantiomer 1::US10034861, Example 119::US10034861, Example 120::US10512632, Example 120::US10618913, Example S120::US10766893, Example S120::US10806718, Example 120::US11026923, Example 120::US11634416, Example 120

SMILES CCOc1ncccc1-c1cc(NCc2cc[nH]n2)c2n(nc(C)c2n1)C(C)CC

InChI Key

Data  39 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 39 hits for monomerid = 279088   

LigandPNGBDBM279088(5-(2-ethoxy-3-pyridyl)-3-methyl-1-[1-methylpropyl]...)
Affinity DataIC50:  12nMpH: 7.6 T: 25°CAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

LigandPNGBDBM279088(5-(2-ethoxy-3-pyridyl)-3-methyl-1-[1-methylpropyl]...)
Affinity DataIC50:  7.60nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

LigandPNGBDBM279088(5-(2-ethoxy-3-pyridyl)-3-methyl-1-[1-methylpropyl]...)
Affinity DataIC50:  29nMpH: 7.6 T: 25°CAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

LigandPNGBDBM279088(5-(2-ethoxy-3-pyridyl)-3-methyl-1-[1-methylpropyl]...)
Affinity DataIC50:  4.60nMpH: 7.6 T: 25°CAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

LigandPNGBDBM279088(5-(2-ethoxy-3-pyridyl)-3-methyl-1-[1-methylpropyl]...)
Affinity DataIC50:  0.270nMpH: 7.6 T: 25°CAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

LigandPNGBDBM279088(5-(2-ethoxy-3-pyridyl)-3-methyl-1-[1-methylpropyl]...)
Affinity DataIC50:  7.60nMpH: 7.6 T: 25°CAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

LigandPNGBDBM279088(5-(2-ethoxy-3-pyridyl)-3-methyl-1-[1-methylpropyl]...)
Affinity DataIC50:  12nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

LigandPNGBDBM279088(5-(2-ethoxy-3-pyridyl)-3-methyl-1-[1-methylpropyl]...)
Affinity DataIC50:  0.560nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

LigandPNGBDBM279088(5-(2-ethoxy-3-pyridyl)-3-methyl-1-[1-methylpropyl]...)
Affinity DataIC50:  29nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

LigandPNGBDBM279088(5-(2-ethoxy-3-pyridyl)-3-methyl-1-[1-methylpropyl]...)
Affinity DataIC50:  4.60nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

LigandPNGBDBM279088(5-(2-ethoxy-3-pyridyl)-3-methyl-1-[1-methylpropyl]...)
Affinity DataIC50:  0.270nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

LigandPNGBDBM279088(5-(2-ethoxy-3-pyridyl)-3-methyl-1-[1-methylpropyl]...)
Affinity DataIC50:  7.60nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

LigandPNGBDBM279088(5-(2-ethoxy-3-pyridyl)-3-methyl-1-[1-methylpropyl]...)
Affinity DataIC50:  4.60nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

LigandPNGBDBM279088(5-(2-ethoxy-3-pyridyl)-3-methyl-1-[1-methylpropyl]...)
Affinity DataIC50:  0.270nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

LigandPNGBDBM279088(5-(2-ethoxy-3-pyridyl)-3-methyl-1-[1-methylpropyl]...)
Affinity DataIC50:  7.60nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

LigandPNGBDBM279088(5-(2-ethoxy-3-pyridyl)-3-methyl-1-[1-methylpropyl]...)
Affinity DataIC50:  12nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

LigandPNGBDBM279088(5-(2-ethoxy-3-pyridyl)-3-methyl-1-[1-methylpropyl]...)
Affinity DataIC50:  0.560nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

LigandPNGBDBM279088(5-(2-ethoxy-3-pyridyl)-3-methyl-1-[1-methylpropyl]...)
Affinity DataIC50:  29nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

LigandPNGBDBM279088(5-(2-ethoxy-3-pyridyl)-3-methyl-1-[1-methylpropyl]...)
Affinity DataIC50:  4.60nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

LigandPNGBDBM279088(5-(2-ethoxy-3-pyridyl)-3-methyl-1-[1-methylpropyl]...)
Affinity DataIC50:  0.270nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

LigandPNGBDBM279088(5-(2-ethoxy-3-pyridyl)-3-methyl-1-[1-methylpropyl]...)
Affinity DataIC50:  7.60nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

LigandPNGBDBM279088(5-(2-ethoxy-3-pyridyl)-3-methyl-1-[1-methylpropyl]...)
Affinity DataIC50:  12nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

LigandPNGBDBM279088(5-(2-ethoxy-3-pyridyl)-3-methyl-1-[1-methylpropyl]...)
Affinity DataIC50:  0.560nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

LigandPNGBDBM279088(5-(2-ethoxy-3-pyridyl)-3-methyl-1-[1-methylpropyl]...)
Affinity DataIC50:  29nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

LigandPNGBDBM279088(5-(2-ethoxy-3-pyridyl)-3-methyl-1-[1-methylpropyl]...)
Affinity DataIC50:  4.60nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

LigandPNGBDBM279088(5-(2-ethoxy-3-pyridyl)-3-methyl-1-[1-methylpropyl]...)
Affinity DataIC50:  0.270nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

LigandPNGBDBM279088(5-(2-ethoxy-3-pyridyl)-3-methyl-1-[1-methylpropyl]...)
Affinity DataIC50:  7.60nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

LigandPNGBDBM279088(5-(2-ethoxy-3-pyridyl)-3-methyl-1-[1-methylpropyl]...)
Affinity DataIC50:  12nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 uL samples containing a fixed amount of the PDE1 enzyme (suff...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

LigandPNGBDBM279088(5-(2-ethoxy-3-pyridyl)-3-methyl-1-[1-methylpropyl]...)
Affinity DataIC50:  0.560nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 uL samples containing a fixed amount of the PDE1 enzyme (suff...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

LigandPNGBDBM279088(5-(2-ethoxy-3-pyridyl)-3-methyl-1-[1-methylpropyl]...)
Affinity DataIC50:  29nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 uL samples containing a fixed amount of the PDE1 enzyme (suff...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

LigandPNGBDBM279088(5-(2-ethoxy-3-pyridyl)-3-methyl-1-[1-methylpropyl]...)
Affinity DataIC50:  4.60nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 uL samples containing a fixed amount of the PDE1 enzyme (suff...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

LigandPNGBDBM279088(5-(2-ethoxy-3-pyridyl)-3-methyl-1-[1-methylpropyl]...)
Affinity DataIC50:  0.270nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 uL samples containing a fixed amount of the PDE1 enzyme (suff...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

LigandPNGBDBM279088(5-(2-ethoxy-3-pyridyl)-3-methyl-1-[1-methylpropyl]...)
Affinity DataIC50:  7.60nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 uL samples containing a fixed amount of the PDE1 enzyme (suff...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

LigandPNGBDBM279088(5-(2-ethoxy-3-pyridyl)-3-methyl-1-[1-methylpropyl]...)
Affinity DataIC50:  12nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

LigandPNGBDBM279088(5-(2-ethoxy-3-pyridyl)-3-methyl-1-[1-methylpropyl]...)
Affinity DataIC50:  0.560nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

LigandPNGBDBM279088(5-(2-ethoxy-3-pyridyl)-3-methyl-1-[1-methylpropyl]...)
Affinity DataIC50:  29nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

LigandPNGBDBM279088(5-(2-ethoxy-3-pyridyl)-3-methyl-1-[1-methylpropyl]...)
Affinity DataIC50:  4.60nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

LigandPNGBDBM279088(5-(2-ethoxy-3-pyridyl)-3-methyl-1-[1-methylpropyl]...)
Affinity DataIC50:  0.270nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

LigandPNGBDBM279088(5-(2-ethoxy-3-pyridyl)-3-methyl-1-[1-methylpropyl]...)
Affinity DataIC50:  0.560nMpH: 7.6 T: 25°CAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent