BDBM287795 2-[6-(2,3-dihydro-1H- inden-2-ylcarbonyl)-6,11- dihydro-5H-pyrido[2,3-b] [1,5]benzodiazepin-8- yl]-2-methylpropanenitrile::US10086000, Example 13::US10508108, Example 13

SMILES CC(C)(C#N)c1ccc2Nc3ncccc3CN(C(=O)C3Cc4ccccc4C3)c2c1

InChI Key InChIKey=XVLBKVWNIYZCOZ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 287795   

TargetIsocitrate dehydrogenase [NADP] cytoplasmic [R132H](Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM287795(2-[6-(2,3-dihydro-1H- inden-2-ylcarbonyl)-6,11- di...)
Affinity DataIC50:  3nMAssay Description:Each test compound (10 mM stock in DMSO) is diluted in DMSO to make a 10-point, 3-fold dilution series. 125 nL of each dilution or DMSO alone is disp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetIsocitrate dehydrogenase [NADP] cytoplasmic [R132H](Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM287795(2-[6-(2,3-dihydro-1H- inden-2-ylcarbonyl)-6,11- di...)
Affinity DataIC50:  3nMpH: 7.0 T: 2°CAssay Description:Each test compound (10 mM stock in DMSO) is diluted in DMSO to make a 10-point, 3-fold dilution series. 125 nL of each dilution or DMSO alone is disp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent