BDBM287910 (R)-(2,3-Dihydrobenzo[b][1,4]dioxin-2-yl)(8-(3,3,3-trifluoropropyl)-5,11-dihydro-6H-benzo[b]pyrido[2,3-e][1,4]diazepin-6-yl)methanone::US10086000, Example 127::US10508108, Example 127

SMILES FC(F)(F)CCc1ccc2Nc3ncccc3CN(C(=O)[C@H]3COc4ccccc4O3)c2c1

InChI Key InChIKey=LRROYLUTEOAHEC-OAQYLSRUSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 287910   

TargetIsocitrate dehydrogenase [NADP] cytoplasmic [R132H](Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM287910((R)-(2,3-Dihydrobenzo[b][1,4]dioxin-2-yl)(8-(3,3,3...)
Affinity DataIC50:  120nMAssay Description:Each test compound (10 mM stock in DMSO) is diluted in DMSO to make a 10-point, 3-fold dilution series. 125 nL of each dilution or DMSO alone is disp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetIsocitrate dehydrogenase [NADP] cytoplasmic [R132H](Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM287910((R)-(2,3-Dihydrobenzo[b][1,4]dioxin-2-yl)(8-(3,3,3...)
Affinity DataIC50:  120nMpH: 7.0 T: 2°CAssay Description:Each test compound (10 mM stock in DMSO) is diluted in DMSO to make a 10-point, 3-fold dilution series. 125 nL of each dilution or DMSO alone is disp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent