BDBM294025 (2S)-5-(2-(4-((3- Cyclopropylbenzo[b]thiophen- 5-yl)methoxy)phenyl)pent-3-yn- 1-yl)-1H-tetrazole::US10106553, Compound 57

SMILES CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3scc(C4CC4)c3c2)cc1

InChI Key

Data  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 294025   

TargetFree fatty acid receptor 1(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM294025((2S)-5-(2-(4-((3- Cyclopropylbenzo[b]thiophen- 5-y...)
Affinity DataEC50:  860nMT: 2°CAssay Description:Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFree fatty acid receptor 1(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM294025((2S)-5-(2-(4-((3- Cyclopropylbenzo[b]thiophen- 5-y...)
Affinity DataEC50:  858nMAssay Description:Agonist activity at human GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Rattus norvegicus)TBA
LigandPNGBDBM294025((2S)-5-(2-(4-((3- Cyclopropylbenzo[b]thiophen- 5-y...)
Affinity DataEC50:  239nMAssay Description:Agonist activity at rat GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed