BDBM307682 2-(6-(4-cyclopropyl-4H-1,2,4-triazol-3-yl)pyridin-2-yl)-N,N-dimethyl-3-oxoisoindoline-5-carboxamide ::US10150755, Compound 2::US10150755, Compound 74

SMILES CN(C)C(=O)c1ccc2CN(C(=O)c2c1)c1cccc(n1)-c1nncn1C1CC1

InChI Key InChIKey=SADRMVXUFCEHJG-UHFFFAOYSA-N

Data  3 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 307682   

TargetMitogen-activated protein kinase kinase kinase 5(Homo sapiens (Human))
Seal Rock Therapeutics

US Patent
LigandPNGBDBM307682(2-(6-(4-cyclopropyl-4H-1,2,4-triazol-3-yl)pyridin-...)
Affinity DataKi: <200nMAssay Description:The ASK1 enzymatic assay was run following Promega ASK1 Kinase Enzyme System (Cat #V3881). The kit provides the protocol, enzymes and all reagents ne...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase 5(Homo sapiens (Human))
Seal Rock Therapeutics

US Patent
LigandPNGBDBM307682(2-(6-(4-cyclopropyl-4H-1,2,4-triazol-3-yl)pyridin-...)
Affinity DataKi:  600nMAssay Description:The ASK1 enzymatic assay was run following Promega ASK1 Kinase Enzyme System (Cat #V3881). The kit provides the protocol, enzymes and all reagents ne...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMyosin light chain kinase, smooth muscle(Homo sapiens (Human))
Seal Rock Therapeutics

US Patent
LigandPNGBDBM307682(2-(6-(4-cyclopropyl-4H-1,2,4-triazol-3-yl)pyridin-...)
Affinity DataKi:  5.50E+3nMAssay Description:MYLK dissociation constants (Kd) for compounds were determined using the DiscoverX KdELECT platform. The MYLK kinase (accession number NP_444254.3) w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTumor necrosis factor(Homo sapiens (Human))
Seal Rock Therapeutics

US Patent
LigandPNGBDBM307682(2-(6-(4-cyclopropyl-4H-1,2,4-triazol-3-yl)pyridin-...)
Affinity DataIC50:  600nMAssay Description:Cryopreserved human PBMCs were obtained from AllCells (cat# PB003F). After thawing/dilution protocols using RPMI medium supplemented with 5% FBS (hea...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase 5(Homo sapiens (Human))
Seal Rock Therapeutics

US Patent
LigandPNGBDBM307682(2-(6-(4-cyclopropyl-4H-1,2,4-triazol-3-yl)pyridin-...)
Affinity DataIC50:  600nMAssay Description:The ASK1 enzymatic assay was run following Promega ASK1 Kinase Enzyme System (Cat #V3881). The kit provides the protocol, enzymes and all reagents ne...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent