BDBM322895 2-(azepan-1-yl)-4-((4-(4-(1-hydroxy-2- methylpropan-2-yl)piperazin-1-yl)phenyl) amino)pyrimido[4,5-d]pyridazin-5(6H)- one::US10183944, Example 265::US10647720, Ex. # 265

SMILES CC(C)(CO)N1CCN(CC1)c1ccc(Nc2nc(nc3cn[nH]c(=O)c23)N2CCCCCC2)cc1

InChI Key InChIKey=IRDRLRREQPEXIC-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 322895   

TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Asana Biosciences

US Patent
LigandPNGBDBM322895(2-(azepan-1-yl)-4-((4-(4-(1-hydroxy-2- methylpropa...)
Affinity DataIC50: <10nMAssay Description:2.5 μL of 10% DMSO or compound in 10% DMSO was added to the wells in a 96 well V-bottom plate. Optimized concentration of in-house Syk enzyme (d...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Asan Biosciences

US Patent
LigandPNGBDBM322895(2-(azepan-1-yl)-4-((4-(4-(1-hydroxy-2- methylpropa...)
Affinity DataIC50: <10nMAssay Description:Two μL of 10% DMSO in blank, substrate control and positive control wells and 2 μL of test compound in test wells was added. Thirteen μ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Asana Biosciences

US Patent
LigandPNGBDBM322895(2-(azepan-1-yl)-4-((4-(4-(1-hydroxy-2- methylpropa...)
Affinity DataIC50: <10nMAssay Description:2.5 μL of 10% DMSO or compound in 10% DMSO was added to the wells in a 96 well V-bottom plate. Optimized concentration of in-house Syk enzyme (d...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Asan Biosciences

US Patent
LigandPNGBDBM322895(2-(azepan-1-yl)-4-((4-(4-(1-hydroxy-2- methylpropa...)
Affinity DataIC50: <10nMAssay Description:Two μL of 10% DMSO in blank, substrate control and positive control wells and 2 μL of test compound in test wells was added. Thirteen μ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent