BDBM329034 4-(6-(3,5-dichlorophenoxy)-5- (difluoromethyl)-3-pyridinyl)- 3-methoxy-N- (methylsulfonyl)benzamide::4-(6-(3,5-dichlorophenoxy)-5-(difluoromethyl)-3-pyridinyl)-3-methoxy-N-(methylsulfonyl)benzamide::US9663508, Example 382

SMILES COc1cc(ccc1-c1cnc(Oc2cc(Cl)cc(Cl)c2)c(c1)C(F)F)C(=O)NS(C)(=O)=O

InChI Key InChIKey=WIBVLJJJUJRQFE-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 329034   

TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM329034(4-(6-(3,5-dichlorophenoxy)-5- (difluoromethyl)-3-p...)
Affinity DataIC50:  54nMAssay Description:HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM329034(4-(6-(3,5-dichlorophenoxy)-5- (difluoromethyl)-3-p...)
Affinity DataIC50:  54nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293 cells incubated for 3 to 5 mins at -125 mV holding potential by electrophysiology assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM329034(4-(6-(3,5-dichlorophenoxy)-5- (difluoromethyl)-3-p...)
Affinity DataIC50:  1.88E+4nMAssay Description:Inhibition of human Nav1.5 expressed in HEK293 cells incubated for 3 to 5 mins at -50 mV holding potential by electrophysiology assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed