BDBM354783 6-(4-amino-3- methoxyphenyl)-1-(1H- indol-5-yl)-1H-imidazo[4,5- b]pyrazin-2(3H)-one::US10485800, Example 60::US9814704, Example 60

SMILES COc1cc(ccc1N)-c1cnc2[nH]c(=O)n(-c3ccc4[nH]ccc4c3)c2n1

InChI Key InChIKey=IJMBLAWBIHCSHO-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 354783   

TargetMitogen-activated protein kinase kinase kinase 11(Homo sapiens (Human))
The University of Rochester

US Patent
LigandPNGBDBM354783(6-(4-amino-3- methoxyphenyl)-1-(1H- indol-5-yl)-1H...)
Affinity DataIC50: <100nMAssay Description:200 ng (130 nM) MLK3 (Dundee, DU8313) was incubated with 1 μM inactive MKK7b (Dundee, DU703) in the presence of 2 μM cold ATP (Km) and 0.5 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase 11(Homo sapiens (Human))
The University of Rochester

US Patent
LigandPNGBDBM354783(6-(4-amino-3- methoxyphenyl)-1-(1H- indol-5-yl)-1H...)
Affinity DataIC50: <100nMAssay Description:200 ng (130 nM) MLK3 (Dundee, DU8313) was incubated with 1 μM inactive MKK7b (Dundee, DU703) in the presence of 2 μM cold ATP (Km) and 0.5 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent