BDBM35596 pyrazolo pyrimidine, 5a
SMILES Oc1cccc(c1)-c1nc(N2CCOCC2)c2cnn(C3CCNCC3)c2n1
InChI Key InChIKey=WCZSBHYATWRXOI-UHFFFAOYSA-N
Data 6 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 6 hits for monomerid = 35596
Affinity DataIC50: 215nMpH: 7.4 T: 2°CAssay Description:The enzyme was assayed in DELFIA format using purified FLAG-TOR in kinase buffer containing ATP and His6-S6K in the presence of inhibitor compounds. ...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Wyeth Research
Wyeth Research
Affinity DataIC50: 36nMT: 2°CAssay Description:Inhibition of PI3K enzyme activity is measured in a microtiter plate-based fluorescence polarization (FP) assay. More data for this Ligand-Target Pair
Affinity DataIC50: 220nMAssay Description:Inhibition of recombinant FLAG-tagged mTOR (unknown origin) expressed in HEK293 cells assessed as decrease in phosphorylation of S6K level at Thr389 ...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Wyeth Research
Curated by ChEMBL
Wyeth Research
Curated by ChEMBL
Affinity DataIC50: 993nMAssay Description:Inhibition of GST-GRP1-fused PI3Kgamma by microtiter plate based fluorescence polarization assayMore data for this Ligand-Target Pair
Affinity DataIC50: 215nMAssay Description:Inhibition of human TOR in HEK293 cells by DELFIAMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Wyeth Research
Curated by ChEMBL
Wyeth Research
Curated by ChEMBL
Affinity DataIC50: 36nMAssay Description:Inhibition of GST-GRP1-fused PI3Kalpha by microtiter plate based fluorescence polarization assayMore data for this Ligand-Target Pair