BDBM363485 3-chloro-4-(9-(2-hydroxy-2-(2- methyl-6-(1H-tetrazol-1- yl)pyridin-3-yl)ethyl)-1-oxa-4,9- diazaspiro[5.5]undecan-4- yl)furan-2(5H)-one (single diastereomer, absolute stereochemistry not established)::US9850245, Example 25A

SMILES Cc1nc(ccc1C(O)CN1CCC2(CC1)CN(CCO2)C1=C(Cl)C(=O)OC1)-n1cnnn1

InChI Key InChIKey=PXGJKROHUIIVBA-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 363485   

TargetATP-sensitive inward rectifier potassium channel 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM363485(3-chloro-4-(9-(2-hydroxy-2-(2- methyl-6-(1H-tetraz...)
Affinity DataIC50:  16nMAssay Description:Blocking of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent